Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis

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dc.contributor.authorGüler, Beril
dc.contributor.authorÖzyılmaz, Filiz
dc.contributor.authorTokuç, Burcu
dc.contributor.authorCan, Nuray
dc.contributor.authorTaştekin, Ebru
dc.date.accessioned2021-11-20T10:10:01Z
dc.date.available2021-11-20T10:10:01Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.description.abstractBackground: Gastrointestinal stromal tumors (GIST) have KIT or platelet-derived growth factor receptor ? (PDGFR?) mutations affecting receptor tyrosine ki-nase activity and do not benefit from classic treatment regimens.Aims: The aim of this study was to review the al-gorithm that may be followed for the diagnosis and differential diagnosis in GISTs by investigating the histomorphological parameters and expression charac-teristics of classical immunohistochemical antibodies used in routine tests in addition to DOG1 expression.Study Design: Diagnostic accuracy study.Methods: We reevaluated the histological and immu-nohistochemical parameters of 37 GISTs. The standard immunohistochemical diagnosis and differential diag-nosis panel antibodies (CD117, PDGFR?, CD34, vi-mentin, desmin, SMA, S-100, and Ki67) were studied on the tumor sections. We also used the popular marker DOG1 antibody with accepted sensitivity for GISTs in recent years and the PDGFR? immune marker for which the benefit in routine practice is discussed.Results: Classification according to progressive dis-ease risk groups of the 37 cases revealed that 54% were in the high risk, 19% in the moderate risk, 16% in the low risk, 8% in the very low risk and 8% in the no risk group.Cytological atypia, necrosis, mucosal invasion and the Ki67 index were found to be related to the progressive disease risk groups of the tumors (p<0.05).Positive immunoreaction was observed with CD117 and PDGFR? in all GISTs in the study (100%). Posi-tivity with the DOG1 antibody was found in 33 (89%) cases. CD34 was positive in 62% (23) of the cases.Conclusion: The CD117 antibody still plays a key role in GIST diagnosis. However, the use of DOG1 and PDGFR? antibodies combined with CD117 as sensitive markers can be beneficialen_US
dc.identifier.doi10.5152/balkanmedj.2015.15912en_US
dc.identifier.endpage396en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84943549970en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage388en_US
dc.identifier.trdizinid197564en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRrM05UWTBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5469
dc.identifier.volume32en_US
dc.identifier.wosWOS:000362846400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCerrahien_US
dc.titleHistopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosisen_US
dc.typeArticleen_US

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