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Öğe Metals and phosphorus in the sediments of streams emptying into the Çanakkale strait (Dardanelles): Spatial distribution, pollution status, risk assessment and source identification(Academic Press Inc Elsevier Science, 2024) Varol, Memet; Tokatli, CemThe & Ccedil;anakkale Strait is exposed to various pollutants due to its strategic location. It is thought that stream inputs may contribute significantly to metal and phosphorus (P) accumulation in the strait. In this study, the spatial distribution, pollution status, ecological risks and possible sources of twelve metals and P in the sediments of seven important streams emptying into the strait were analyzed. The results showed that Zn (226 mg/kg), Ba (67.2 mg/kg) and Pb (10.4 mg/kg) concentrations were higher in the Umurbey Stream due to mining activities, while P concentration (295 mg/kg) was higher in the & Ccedil;anakkale Stream due to both agricultural activities and domestic wastewater discharges. Modified hazard quotient (mHQ), enrichment factor (EF) and contamination factor (Cf) values revealed that Zn and Pb showed high and moderate contamination in the US3 and US4 sampling sites of the Umurbey Stream, respectively. Similarly, P showed moderate contamination in the & Ccedil;S3 site of the & Ccedil;anakkale Stream. Nemerow pollution index (NPI) showed that the US3 (2.41) and US4 (4.28) sites of the Umurbey Stream were slightly and moderately polluted, respectively. Toxic risk index (TRI) values demonstrated that the sediments in only the US4 site (5.17) of the Umurbey Stream may pose a low toxic risk due to high Zn content. Similarly, based on comparison results with sediment quality guidelines (SQGs), it was found that high Zn content may lead to adverse effects on sediment-dwelling organisms in the US4 site. In addition, the PECquotient value in the US4 site exceeded 0.5, confirming the finding that the sediments in this site could be toxic to benthic organisms. Finally, correlation, cluster and factor analyzes were used to determine possible sources of elements. Mining activities, natural sources and mixed sources (agricultural activities and natural sources) were identified as the main sources of elements in the sediments of the streams. This study can provide an important reference for evaluating stream sediment pollution and managing marine pollution.Öğe Revisiting Classical 3?-hydroxysteroid Dehydrogenase 2 Deficiency: Lessons from 31 Pediatric Cases(Endocrine Soc, 2020) Guran, Tulay; Kara, Cengiz; Yildiz, Melek; Bitkin, Eda C.; Haklar, Goncagul; Lin, Jen-Chieh; Keskin, MehmetContext: The clinical effects of classical 3 beta-hydroxysteroid dehydrogenase 2 (3 beta HSD2) deficiency are insufficiently defined due to a limited number of published cases. Objective: To evaluate an integrated steroid metabolome and the short- and long-term clinical features of 3 beta HSD2 deficiency. Design: Multicenter, cross-sectional study. Setting: Nine tertiary pediatric endocrinology clinics across Turkey. Patients: Children with clinical diagnosis of 3 beta HSD2 deficiency. Main Outcome Measures: Clinical manifestations, genotype-phenotype-metabolomic relations. A structured questionnaire was used to evaluate the data of patients with clinical 3 beta HSD2 deficiency. Genetic analysis of HSD3B2 was performed using Sanger sequencing. Novel HSD3B2 mutations were studied in vitro. Nineteen plasma adrenal steroids were measured using LC-MS/MS. Results: Eleven homozygous HSD3B2 mutations (6 novel) were identified in 31 children (19 male/12 female; mean age: 6.6 +/- 5.1 yrs). The patients with homozygous pathogenic HSD3B2 missense variants of > 5% of wild type 3 beta HSD2 activity in vitro had a non-salt-losing clinical phenotype. Ambiguous genitalia was an invariable feature of all genetic males, whereas only 1 of 12 female patients presented with virilized genitalia. Premature pubarche was observed in 78% of patients. In adolescence, menstrual irregularities and polycystic ovaries in females and adrenal rest tumors and gonadal failure in males were observed. Conclusions: Genetically-documented 3 beta HSD2 deficiency includes salt-losing and non-salt-losing clinical phenotypes. Spared mineralocorticoid function and unvirilized genitalia in females may lead to misdiagnosis and underestimation of the frequency of 3 beta HSD2 deficiency. High baseline 17OHPreg to cortisol ratio and low 11-oxyandrogen concentrations by LC-MS/MS unequivocally identifies patients with 3 beta HSD2 deficiency.Öğe On the behavior of single-particle dynamic properties of liquid Hg and other metals(Amer Inst Physics, 2008) Gonzalez, Luis E.; Gonzalez, David J.; Calderin, Lÿzaro; Sengul, SedatRecent experiments and classical molecular dynamics simulations performed on liquid Hg near melting have suggested the existence of two processes with different time scales in its single-particle dynamics. We report a study of this system by using ab initio molecular dynamics simulations, which recover the same kind of behavior, and we analyze it in terms of a theoretical approach, which clarifies its origin. We show that the previous interpretation has been induced by the unphysical extension of the diffusive model to short times. Moreover, we also find that quite different liquid metals, such as Si and Mg, also exhibit a similar behavior as Hg, with the only difference being in the time scales involved due to the different masses and interactions.Öğe TITLE: DEFINING THE CLINICAL AND PROGNOSTIC LANDSCAPE OF EMBRYONAL TUMORS WITH MULTI-LAYERED ROSETTES (ETMRS), A RARE BRAIN TUMOR REGISTRY (RBTC) STUDY(Oxford Univ Press Inc, 2020) Khan, Sara; Solano-Paez, Palma; Suwal, Tannu; Al-Karmi, Salma; Lu, Mei; Ho, Ben; Fouladi, Maryam[Abstract Not Available]Öğe THE RELATIONSHIP BETWEEN SEVERITY OF INTERSTITIAL FIBROSIS AND ANEMIA IN PATIENT WITH PRIMARY GLOMERULONEPHRITIS: THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Cebeci, Egemen; Turgutalp, Kenan; Ozturk, Savas; Ozluk, Yasemin; Bek, Sibel Gokcay; Sumnu, Abdullah; Seyahi, Nurhan[Abstract Not Available]Öğe TRENDS OF PRIMARY GLOMERULAR DISEASE IN TURKEY FROM 2009 TO 2017: A REGIONAL REGISTRY REPORT FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Gul, Cuma Bulent; Kucuk, Mehmet; Ozturk, Savas; Demir, Erol; Eren, Necmi; Sumnu, Abdullah; Seyahi, Nurhan[Abstract Not Available]Öğe USE OF ELTROMBOPAG IN IMMUNE THROMBOCYTOPENIA IN TURKEY(Pergamon-Elsevier Science Ltd, 2016) Cekdemir, D.; Ozdemirkiran, F.; Guvenc, S.; Eser, A.; Ozkocaman, V.; Sahin, H. H.; Turak, E. E.[Abstract Not Available]Öğe THE LONGITUDINAL EVOLUTION OF COVID-19 OUTCOMES AMONG HEMODIALYSIS PATIENTS: A NATIONWIDE MULTICENTRE CONTROLLED STUDY(Oxford Univ Press, 2022) Ozturk, Savas; Turgutalp, Kenan; Arici, Mustafa; Gorgulu, Numan; Tonbul, Halil Zeki; Eren, Necmi; Gencer, Vedat[Abstract Not Available]Öğe THE PREVALENCE, CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN TURKISH ADULTS: THE DATA FROM TSN-GOLD (TURKISH SOCIETY OF NEPHROLOGY GLOMERULAR DISEASES) WORKING GROUP(Oxford Univ Press, 2020) Kurultak, Ilhan; Gungor, Ozkan; Ozturk, Savas; Dirim, Ahmet Burak; Eren, Necmi; Yenigun, Ezgi; Dal, Elbis Ahbap[Abstract Not Available]Öğe CLINICAL, EPIDEMIOLOGICAL AND PROGNOSTIC FEATURES OF CHILDREN WITH HEMOLYTIC UREMIC SYNDROME: MULTICENTER EXPERIENCE OF TURKEY(Springer, 2018) Ertan, Pelin; Bulut, Ipek Kaplan; Guven, Sercin; Cicek, Neslihan; Tulpar, Sebahat; Coskun, Seda; Donmez, Osman[Abstract Not Available]Öğe CHARACTERISTICS AND SURVIVAL DATA OF PATIENTS WITH PRIMARY FOCAL SEGMENTAL SEGMENTAL GLOMERULOSCLEROSIS: TSN-GOLDMULTI-CENTER STUDY(Oxford Univ Press, 2023) Dheir, Hamad; Cebeci, Egemen; Karadag, Serhat; Yildiz, Abdulmecit; Guller, Nurana; Altiparmak, Mehmet Riza; Eren, Necmi[Abstract Not Available]Öğe Diagnostic testing for penicillin allergy: Practices and cost perceptions in Europe and North America(Wiley, 2019) Sousa-Pinto, B. M.; Blumenthal, K. G.; Macy, E.; Bavbek, S.; Benic, M. S.; Alves-Correia, M.; Dursun, A. B.[Abstract Not Available]Öğe Items of Yamaguchi Criteria Might be Associated with Disease Severity and Prognosis in Adult-Onset Still's Disease(Wiley, 2015) Kalyoncu, Umut; Solmaz, Dilek; Emmungil, Hakan; Yazici, Ayten; Kasifoglu, Timucin; Kimyon, Gezmis; Balkarli, Ayse[Abstract Not Available]Öğe EPIDEMIOLOGICAL AND CLINICAL CHARACTERSTICS OF IGA NEPHROPATHY PATIENTS IN TURKEY: TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Eren, Necmi; Gursu, Meltem; Cebeci, Egemen; Turkmen, Aydin; Yeter, Hasan Haci; Seyahi, Nurhan; Piskinpasa, Serhan Vahit[Abstract Not Available]Öğe URINARY HSP70 IMPROVES DIAGNOSTIC ACCURACY FOR URINARY TRACT INFECTION IN CHILDREN: UTILISE STUDY(Springer, 2022) Yilmaz, Alev; Afonso, Alberto Caldas; Akil, Ipek; Aksu, Bagdagul; Alpay, Harika; Atmis, Bahriye; Aydog, Ozlem[Abstract Not Available]Öğe Characteristics of food allergy in children: National multicenter study(Wiley, 2019) Bingol, A.; Uygun, Kocacik D. F.; Akdemir, M.; Erengin, H.; Bozdogan, G.; Bingol, G.; Orhan, F.[Abstract Not Available]Öğe CHARACTERISTICS OF PRIMARY GLOMERULAR DISEASE PATIENTS WITH HEMATURIA IN TURKEY: THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Sumnu, Abdullah; Turkmen, Kultigin; Cebeci, Egemen; Turkmen, Aydin; Eren, Necmi; Seyahi, Nurhan; Oruc, Aysegul[Abstract Not Available]Öğe IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Turgutalp, Kenan; Cebeci, Egemen; Turkmen, Aydin; Derici, Ulver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih[Abstract Not Available]Öğe The natural history study of hidradenitis suppurativa: A large-scale multicenter study in turkey(Wiley, 2023) Alpsoy, Erkan; Karaman, Bilge Fettahlioglu; Demirseren, Deniz; Cinar, Levent; Kacar, Nida; Ermertcan, Aylin Turel; Baskan, Emel Bulbul[Abstract Not Available]Öğe Patterns of care for lung cancer in radiation oncology departments of Turkey(Elsevier Ireland Ltd, 2006) Demiral, A.; Alicikus, Z. Arican; Ugur, V.; Karadogan, I.; Yoney, A.; Andrieu, M. Nalca; Yalman, D.[Abstract Not Available]
