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Öğe C-reactive protein and body mass index in women with pre-eclampsia(Wiley, 2004) Kilic-Okman, T; Kucuk, M; Ekuklu, G[Abstract Not Available]Öğe Comparison of the effects of letrozole and clompiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat(Elsevier Science Inc, 2003) Kilic-Okman, T; Kucuk, M; Altaner, SObjective: To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E-2, FSH, LH, and T. Design: Controlled prospective study. Setting: University research laboratory. Animal(s): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. Intervention(s): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 mug/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. Main Outcome Measure(s): Number of mature follicles, endometrial thickness, and serum levels of hormones. Result(s): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. Conclusion(s): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate. (C) 2003 by American Society for Reproductive Medicine.Öğe The effects of antihypertensive agents on endometrial thickness in asymptomatic, hypertensive, postmenopausal women(Lippincott Williams & Wilkins, 2003) Okman-Kilic, T; Kucuk, MObjective: The aim of this study was to investigate, by using transvaginal ultrasonography, the possible effects on endometrial thickness of antihypertensive agents in asymptomatic postmenopausal women. Design: A prospective study in an outpatient menopause clinic of a university hospital. We included 288 postmenopausal women in this study, and we compared three groups of postmenopausal women as follows: (1) normotensive postmenopausal women, (2) hypertensive women treated with an antihypertensive drug (beta-blocker, non-beta-blocker, or beta-blocker plus non-p-blocker), and (3) untreated hypertensive women who had had hypertension for at least 1 year. Hypertensive women treated with a drug had been receiving treatment for 1 year. All women were interviewed and examined. Measurements of endometrial thickness were carried out by vaginal ultrasonography. Results: Sixty-two women (22%) were normotensive, and 226 (78%) of 288 women were hypertensive. Of the 226 women, 122 (54%) were receiving an antihypertensive drug. The mean (+/- SD) endometrial thicknesses in groups A, B, and C were 4.5 (+/- 1.3), 5.4 (+/- 1.5), and 6.4 (+/- 1.7) mm, respectively. Significant difference was obtained among the groups (P = 0.004). Conclusions: Our data indicate that the mean endometrial thickness is significantly greater in asymptomatic, hypertensive women receiving antihypertensive drugs than among untreated hypertensive and normotensive women.Öğe Hormone profiles and clinical outcome after laparoscopic ovarian drilling in women with polycystic ovary syndrome(Int Scientific Information, Inc, 2005) Kucuk, M; Kilic-Okman, TBackground: The aim of our study was to evaluate the results of laparoscopic treatment in women with polycystic ovary syndrome, and to compare their response with ovulation, homocysteine levels, hormone profiles and clinical outcome before and after drilling. Material/Methods: We studied twenty-two nulliparous oligomenorrheic women with polycystic ovaries, complaining of infertility refractory to clomiphene-citrate treatment and subsequently underwent laparoscopic ovarian drilling (LOD) with a needle electrocautery. Endocrine assays, lipoproteins, homocysteine determinations and ultrasound evaluation were performed in all women before and after the procedure. Ovulatory and pregnancy rates and clinical outcome were assessed. Results: After the procedure, serum T, LH, homocysteine levels and LH-FSH ratio were significantly lower than at baseline (0.93+/-0.15 vs 0.67+/-0.11 ng/ml, p<0.001; 12.72+/-1.13 vs 7.36+/-0.57 mIU/ml, p<0.001; 9.77+/-1.06 vs 7.13+/-0.99 mumol/L, p<0.001; 2.16+/-0.22 vs 1.29+/-0.13, p<0.001, respectively). In addition, SHBG levels were higher than at baseline (370.7+/-19.08 vs 404.7+/-16.71 nmol/L, p<0.001) No reduction in high-density lipoprotein cholesterol was observed after the procedure. Similarly, no differences were observed between treating women with LOD and their baseline measurements in E-2, FSH, DHEAS, and PRL concentrations (p=0.255, p=0.140, p=0.250, p=0.137, respectively). Ovulation occurred spontaneously in 77% of women after the procedure. The chance of conception at 12 months after surgery was 54%. Conclusions: LOD appears to be a promising alternative treatment for patients with PCOS. Our results show that LOD may cause a significant reduction in serum concentration of homocysteine in patients with PCOS.Öğe Intrauterine instillation of trichloroacetic acid is effective for the treatment of dysfunctional uterine bleeding(Elsevier Science Inc, 2005) Kucuk, M; Okman, TKObjective: To evaluate the effectiveness of trichloroacetic acid (TCA) instillation into uterine cavity for the treatment of dysfunctional uterine bleeding (DUB). Design: Prospective clinical study. Setting: A university research hospital. Patient(s): Ninety women participated who had dysfunctional uterine bleeding. Intervention(s): Ninety-five percent of TCA was instilled in to uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure. Main Outcome Measure(s): All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy. Result(s): At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rate of 95.6% vs. 97.8%, respectively. There was no significant differences between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment. Conclusion(s): An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB. (C)2005 by American Society for Reproductive Medicine.Öğe Is plasma level of von Willebrand factor the predictor of endothelial dysfunction in women with polycystic ovary syndrome?(Pergamon-Elsevier Science Ltd, 2005) Guldiken, S; Kilic-Okman, T; Demir, M; Arikan, E; Kucuk, M[Abstract Not Available]Öğe N-acetyl-cysteine treatment for polycystic ovary syndrome(Wiley, 2004) Kilic-Okman, T; Kucuk, M[Abstract Not Available]Öğe Non-closure of visceral peritoneum at abdominal hysterectomy(Elsevier Sci Ireland Ltd, 2001) Kucuk, M; Okman, TKOur purpose was to determine whether non-closure of the visceral peritoneum alters post-operative outcome at abdominal hysterectomy. A prospective, randomized trial was performed. Of the 100 evaluable subjects, 50 had the visceral peritoneum left open whereas 50 were closed. Patients were observed for evidence of morbidity after the operation. Analysis of data was performed with use of the unpaired t-test for continuous variables. The visceral peritonization process at abdominal hysterectomy does not provide immediate post-operative benefits while unnecessarily lengthening surgical time and anesthesia exposure. We suggest that visceral peritonization process can be abolished at abdominal hysterectomy. (C) 2001 International Federation of Gynecology and Obstetrics. All rights reserved.Öğe Rectal misoprostol vs. vaginal misoprostol for first trimester termination of pregnancy(Wiley, 2004) Okman-Kilic, T; Kucuk, M[Abstract Not Available]Öğe Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome(Japan Endocrine Society, 2004) Kilic-Okman, T; Guldiken, S; Kucuk, MHyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 +/- 5.86 years) and twenty-five healthy subjects (age, 25.24 +/- 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hey and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hey.
