Comparison of the effects of letrozole and clompiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E-2, FSH, LH, and T. Design: Controlled prospective study. Setting: University research laboratory. Animal(s): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. Intervention(s): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 mug/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. Main Outcome Measure(s): Number of mature follicles, endometrial thickness, and serum levels of hormones. Result(s): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. Conclusion(s): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate. (C) 2003 by American Society for Reproductive Medicine.
Açıklama
Anahtar Kelimeler
Letrozole, Rat, Clomiphene, Endometrium, Follicle, Ovary, Clomiphene Citrate, Stimulating-Hormone, Aromatase Inhibitor, Women, Estrogen
Kaynak
Fertility And Sterility
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
80
Sayı
6
