The Effects of Baicalin on Myoglobinuric Acute Renal Failure in Rats

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dc.contributor.authorYavuz, Özlem Yalçınkaya
dc.contributor.authorAydoğdu, Nurettin
dc.contributor.authorTaştekin, Ebru
dc.contributor.authorSüt, Necdet
dc.date.accessioned2021-11-20T10:10:05Z
dc.date.available2021-11-20T10:10:05Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Anabilim Dalıen_US
dc.description.abstractBackground: Myoglobinuric acute kidney injury is a uremic syndrome that develops due to damage of skeletal muscle. Free radicals and nitric oxide play an important role in the pathogenesis of myoglobinuric acute kidney injury. Baicalin has multiple bioactivities, including antimicrobial, anti-inflammatory and antioxidant properties and is a potent free radical scavenger. Aims: To investigate the nephroprotective mechanism of baicalin on myoglobinuric acute kidney injury. Study Design: Animal experimentation. Methods: In our study, male Sprague Dawley rats were divided into 4 groups. Control (n=8), Baicalin (n=8), myoglobinuric acute kidney injury (n=10) and myoglobinuric acute kidney injury + baicalin (n=10). The rats were deprived of water for 24 hours before receiving intramuscular injection. The control and baicalin groups were injected intramuscularly with saline (8 ml/kg), and the myoglobinuric acute kidney injury and myoglobinuric acute kidney injury + baicalin groups were given 50% glycerol 8 ml/kg. One hour later, the control and myoglobinuric acute kidney injury groups received saline intraperitoneally, and the baicalin and myoglobinuric acute kidney injury + baicalin groups were given 200 mg/kg baicalin. Twenty-four hours after the glycerol injection, urine and blood samples were taken, and the kidneys of the rats were harvested under intraperitoneally injections of anaesthesia. Results: We found that the levels of creatinine, urea, nitric oxide, alanine transaminase, aspartate aminotransferase, creatine kinase in serum samples, malondialdehyde, nitric oxide, inducible nitric oxide synthase, and endothelial nitric oxide synthase concentrations in renal tissue were increased in the myoglobinuric acute kidney injury group compared with the control group (p<0.05). The nitric oxide and glutathione levels in the kidney were significantly decreased in the myoglobinuric acute kidney injury + baicalin group compared with the myoglobinuric acute kidney injury group (p<0.05). There were no significant differences between any other parameters. Conclusion: Our results did not show any protective effect of baicalin on myoglobinuric acute kidney injury, possibly because the different effective factors in the pathogenesis of experimental myoglobinuric acute kidney injury used in this experiment deviate from other experimental models. Moreover, detailed studies are needed to clarify the effects of baicalin in different doses and treatment durations in glycerol-induced acute kidney injury modelen_US
dc.identifier.doi10.4274/balkanmedj.2017.0040en_US
dc.identifier.endpage76en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid28903885en_US
dc.identifier.scopus2-s2.0-85044152556en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.trdizinid280607en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpnd05qQTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5501
dc.identifier.volume35en_US
dc.identifier.wosWOS:000423773000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCerrahien_US
dc.titleThe Effects of Baicalin on Myoglobinuric Acute Renal Failure in Ratsen_US
dc.typeArticleen_US

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