The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes

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dc.authoridUlucam, Enis/0000-0002-4686-7350;
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.contributor.authorUlucam, Enis
dc.contributor.authorBakar, Elvan
dc.date.accessioned2024-06-12T11:02:09Z
dc.date.available2024-06-12T11:02:09Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP - 2009/140]en_US
dc.description.sponsorshipThis research was carried out with the financial support of the Trakya University Scientific Research Projects Unit (Project No: TUBAP - 2009/140).en_US
dc.identifier.doi10.3906/sag-1411-13
dc.identifier.endpage193en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid27511353en_US
dc.identifier.scopus2-s2.0-84953721407en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage185en_US
dc.identifier.trdizinid247807en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1411-13
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/247807
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21172
dc.identifier.volume46en_US
dc.identifier.wosWOS:000368558600015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFormaldehyde Toxicityen_US
dc.subjectMalondialdehydeen_US
dc.subjectProanthocyanidinen_US
dc.subjectSialic Aciden_US
dc.subjectTestisen_US
dc.subjectSerum Sialic-Aciden_US
dc.subjectOxidative Damageen_US
dc.subjectVitamin-Een_US
dc.subjectSeminiferous Tubulesen_US
dc.subjectExtracellular-Matrixen_US
dc.subjectProcyanidin Extracten_US
dc.subjectLipid-Peroxidationen_US
dc.subjectGrapeen_US
dc.subjectExpressionen_US
dc.subjectMelatoninen_US
dc.titleThe effect of proanthocyanidin on formaldehyde-induced toxicity in rat testesen_US
dc.typeArticleen_US

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