Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren’s Syndrome

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dc.contributor.authorUstabaşıoğlu, Fethi Emre
dc.contributor.authorKorkmaz, Selçuk
dc.contributor.authorİlgen, Ufuk
dc.contributor.authorSolak, Serdar
dc.contributor.authorKula, Osman
dc.contributor.authorTuran, Sezin
dc.contributor.authorEmmüngil, Hakan
dc.date.accessioned2021-11-20T10:10:08Z
dc.date.available2021-11-20T10:10:08Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalıen_US
dc.description.abstractBackground: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome. Superb microvascular imaging, power Doppler ultrasound, and color Doppler of the salivary glands represent non-invasive, non-irradiating modality for evaluating the vascularity of the salivary glands in the diagnosis and follow-up of primary Sjögren’s syndrome. Aims: To evaluate the efficacy of superb microvascular imaging and vascularity index in salivary glands for the sonographic diagnosis of primary Sjögren’s syndrome. Study Design: Prospective case-control study. Methods: Twenty participants with primary Sjögren’s syndrome and 20 healthy subjects were included in the study. Both parotid glands and submandibular glands were evaluated by superb microvascular imaging, power Doppler ultrasound, and color Doppler. The diagnostic accuracy of superb microvascular imaging was compared using these techniques. Results: In the patient group, the vascularity index values of superb microvascular imaging in parotid glands and submandibular glands were 3.5±1.66, 5.06±1.94, respectively. While the same values were 1.0±0.98 and 2.44±1.34 in the control group (p?0.001). In the patient group, the vascularity index values of power Doppler ultrasound in parotid glands and submandibular glands were 1.3±1.20 and 2.59±1.82, respectively. While the same values were 0.3±0.32 and 0.85±0.68 in the control group (p?0.001). The superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in parotid glands that maximizes the accuracy was 1.85 (area under the curve: 0.906; 95% confidence interval: 0.844, 0.968), and its sensitivity and specificity were 87.5% and 72.5%, respectively. While the superb microvascular imaging vascularity index cut-off value for the diagnosis of primary Sjögren’s syndrome in submandibular gland that maximizes the accuracy was 3.35 (area under the curve: 0.873; 95% confidence interval: 0.800, 0.946), its sensitivity and specificity were 82.5% and 70%, respectively. Conclusion: Superb microvascular imaging with high reproducibility of the vascularity index has a higher sensitivity and specificity than the power Doppler ultrasound in the diagnosis of primary Sjögren’s syndrome. It can be a noninvasive technique in the diagnosis of primary Sjögren’s syndrome when used with clinical, laboratory and other imaging methods.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2020.2019.11.91en_US
dc.identifier.endpage207en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid32270946en_US
dc.identifier.scopus2-s2.0-85085662933en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage203en_US
dc.identifier.trdizinid372258en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2020.2019.11.91
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpjeU1qVTRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5528
dc.identifier.volume37en_US
dc.identifier.wosWOS:000537456400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subject[No Keywords]en_US
dc.titleQuantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren’s Syndromeen_US
dc.typeArticleen_US

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