The endocannabinoid system as a potential therapeutic target for pain modulation

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dc.contributor.authorUlugöl, Ahmet
dc.date.accessioned2021-11-20T10:10:01Z
dc.date.available2021-11-20T10:10:01Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.description.abstractAlthough cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the enzymes playing a role in endocannabinoid metabolism. Nowadays, research has focused on the inhibition of these degradative enzymes and the elevation of endocannabinoid tonus locally; special emphasis is given on multi-target analgesia compounds, where one of the targets is the endocannabinoid degrading enzyme. In this review, I provide an overview of the current understanding about the processes accounting for the biosynthesis, transport and metabolism of endocannabinoids, and pharmacological approaches and potential therapeutic applications in this area, regarding the use of drugs elevating endocannabinoid levels in pain conditionsen_US
dc.identifier.doi10.5152/balkanmedj.2014.13103en_US
dc.identifier.endpage120en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue2en_US
dc.identifier.pmid25207181en_US
dc.identifier.scopus2-s2.0-84901792205en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage115en_US
dc.identifier.trdizinid168837en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRZNE9ETTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5466
dc.identifier.volume31en_US
dc.identifier.wosWOS:000338061900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlugöl, Ahmet
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCerrahien_US
dc.titleThe endocannabinoid system as a potential therapeutic target for pain modulationen_US
dc.typeArticleen_US

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