A New Tube Gastrostomy Model in Animal Experiments

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dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.contributor.authorSezer, Atakan
dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorCopuroglu, Elif
dc.contributor.authorYagci, Mehmet Ali
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:51:43Z
dc.date.available2024-06-12T10:51:43Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The orogastric route is the most preferred application method in the vast majority of the animal experiments in which application can be achieved by adding the material to the water of the experiment animal, through an orogastric tube or with a surgically managed ostomy. Material and Method: This experiment was constructed with twelve male Sprague-Dawley rats which were randomly assigned to one of two groups consist of control group (group C, n:6) and tube gastrostomy group (group TG, n:6). A novel and simple gastrostomy tube was derivated from a silicone foley catheter. Tube gastrostomy apparatus was constituted with a silicone foley catheter (6 French). In the group TG an incision was performed, and the stomach was visualized. A 1 cm incision was made in the midline and opening of the peritoneum. Anchoring sutures were placed and anterior gastric wall was lifted. The gastric wall is then opened. The apparatus was placed into the stomach and pulled through from a tunnel under the skin and fixed to the lateral abdominal wall with a 2/0 silk suture. Result: The procedure was ended in the 10th day of experiment. No mortality was observed in group C. The rats were monitored daily and no abnormal behavior consists of self harming incision site, resistance to oral intake or attending to displace. There was statistically significant difference in increasing alanine transaminase level (p<0.05) and decrease in the total protein and body weight (p<0.05) at the group TG at the end of experiment. There was significant increase in urea levels in Group C (p<0.05) at the end of experiment. The statistically significant decrease was observed in the same period in group C between aspartate transaminase, albumin, total protein, and body weight (p<0.05). Glucose (p=0.047) and aspartate transaminase (p=0.050) level decrease changes and weight loose (p=0.034) from preoperative period to the end of the experiment between gastrostomy and laparotomy groups were statistically significantly. Discussion: Here in we presented a novel and simple tube gastrostomy model in an experimental rat model in which rats had unrestrained movements. We believe that this new constructed tube gastrostomy model may be an alternative route for the experimental models in which orogastric route is unavailable to use.en_US
dc.identifier.doi10.4328/JCAM.805
dc.identifier.endpage8en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84867017893en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage5en_US
dc.identifier.trdizinid183885en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.805
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/183885
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18468
dc.identifier.volume4en_US
dc.identifier.wosWOS:000215547900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimal Experimentationen_US
dc.subjectExperimental Designsen_US
dc.subjectGastrostomyen_US
dc.titleA New Tube Gastrostomy Model in Animal Experimentsen_US
dc.typeArticleen_US

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