Gamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablation

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dc.authoridACAR, BURAK/0000-0003-3217-5000
dc.authoridÖzeke, Özcan/0000-0002-4770-8159;
dc.authorwosidACAR, BURAK/ABD-9011-2021
dc.authorwosidGÜL, Murat/AAH-7852-2021
dc.authorwosidÖzeke, Özcan/N-1871-2015
dc.authorwosidGUL, Murat/L-5770-2015
dc.authorwosidÖzeke, Özcan/AAS-8730-2020
dc.authorwosidAcar, Burak/GVT-1660-2022
dc.contributor.authorUcar, Fatih Mehmet
dc.contributor.authorIpek, Esra Gucuk
dc.contributor.authorAcar, Burak
dc.contributor.authorGul, Murat
dc.contributor.authorTuncez, Abdullah
dc.contributor.authorOzeke, Ozcan
dc.contributor.authorGeyik, Bilal
dc.date.accessioned2024-06-12T11:02:26Z
dc.date.available2024-06-12T11:02:26Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Catheter ablation is a popular therapy of atrial fibrillation (AF). Gamma-glutamyl transferase (GGT) is known as a marker of oxidative stress. The objective of this study was to ascertain the relationship between levels of GGT and recurrence of AF after catheter ablation. Methods A total of 102 paroxysmal AF patients who underwent cryoballoon catheter ablation were enrolled. Serum samples were obtained to evaluate GGT levels before catheter ablation. Cox regression analysis was used to estimate the predictors of AF recurrence. Results Mean age of the cohort was 49.9 +/- 11.7 and 63% of the patients were male. After a mean follow-up of 20 months, 19 (23%) patients had AF recurrences. The baseline GGT levels were significantly higher in patients who had AF recurrence [27 U/L (17-36) vs 18 U/L (13-22), P=0.0021.The optimal cut-off value of GGT to predict AF recurrence was 23.5 U/L according to receiver operating characteristic curve analysis (area under the curve 0.72, P=0.002). In the multivariable Cox regression analysis, baseline GGT > 23.5 was the only independent predictor of AF recurrence (hazard ratio (HR) 4.47, 95% confidence interval [1.66-12.09], P=0.003). Conclusions Our results indicate that elevated GGT is associated with AF recurrence. A simple measurement of GGT may help us to identify high-risk patients undergoing catheter ablation for AF.en_US
dc.identifier.doi10.1080/AC.71.2.3141851
dc.identifier.endpage210en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue2en_US
dc.identifier.pmid27090043en_US
dc.identifier.scopus2-s2.0-84964000363en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1080/AC.71.2.3141851
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21285
dc.identifier.volume71en_US
dc.identifier.wosWOS:000375351400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGamma-Glutamyl Transferaseen_US
dc.subjectCatheter Ablationen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectOutcomeen_US
dc.subjectOxidative Stressen_US
dc.subjectPulmonary Veinen_US
dc.subjectElectrical Cardioversionen_US
dc.subjectRisk-Factoren_US
dc.subjectDiseaseen_US
dc.subjectTranspeptidaseen_US
dc.subjectInflammationen_US
dc.subjectGlutathioneen_US
dc.subjectPreventionen_US
dc.subjectInfarctionen_US
dc.titleGamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablationen_US
dc.typeArticleen_US

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