Gamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablation
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Catheter ablation is a popular therapy of atrial fibrillation (AF). Gamma-glutamyl transferase (GGT) is known as a marker of oxidative stress. The objective of this study was to ascertain the relationship between levels of GGT and recurrence of AF after catheter ablation. Methods A total of 102 paroxysmal AF patients who underwent cryoballoon catheter ablation were enrolled. Serum samples were obtained to evaluate GGT levels before catheter ablation. Cox regression analysis was used to estimate the predictors of AF recurrence. Results Mean age of the cohort was 49.9 +/- 11.7 and 63% of the patients were male. After a mean follow-up of 20 months, 19 (23%) patients had AF recurrences. The baseline GGT levels were significantly higher in patients who had AF recurrence [27 U/L (17-36) vs 18 U/L (13-22), P=0.0021.The optimal cut-off value of GGT to predict AF recurrence was 23.5 U/L according to receiver operating characteristic curve analysis (area under the curve 0.72, P=0.002). In the multivariable Cox regression analysis, baseline GGT > 23.5 was the only independent predictor of AF recurrence (hazard ratio (HR) 4.47, 95% confidence interval [1.66-12.09], P=0.003). Conclusions Our results indicate that elevated GGT is associated with AF recurrence. A simple measurement of GGT may help us to identify high-risk patients undergoing catheter ablation for AF.
Açıklama
Anahtar Kelimeler
Gamma-Glutamyl Transferase, Catheter Ablation, Atrial Fibrillation, Outcome, Oxidative Stress, Pulmonary Vein, Electrical Cardioversion, Risk-Factor, Disease, Transpeptidase, Inflammation, Glutathione, Prevention, Infarction
Kaynak
Acta Cardiologica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
71
Sayı
2
