Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.contributor.authorSarikaya, A
dc.contributor.authorKarasin, E
dc.contributor.authorÇermik, TF
dc.contributor.authorAbay, E
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T10:59:57Z
dc.date.available2024-06-12T10:59:57Z
dc.date.issued1999
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such studies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood now ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateral parietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.en_US
dc.identifier.doi10.1007/s002590050386
dc.identifier.endpage264en_US
dc.identifier.issn0340-6997
dc.identifier.issue3en_US
dc.identifier.pmid10079317en_US
dc.identifier.scopus2-s2.0-0032991368en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://doi.org/10.1007/s002590050386
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20642
dc.identifier.volume26en_US
dc.identifier.wosWOS:000079149900012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDysthymic Disorderen_US
dc.subjectBrain Single-Photon Emission Tomographyen_US
dc.subjectTechnetium-99m Hexamethylpropyleneen_US
dc.subjectAmine Oximeen_US
dc.subjectCerebral Blood-Flowen_US
dc.subjectMood Disordersen_US
dc.subjectFrontal-Lobeen_US
dc.subjectDepressionen_US
dc.subjectGlucoseen_US
dc.subjectHypometabolismen_US
dc.subjectConsumptionen_US
dc.subjectDiseaseen_US
dc.titleEvaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomographyen_US
dc.typeArticleen_US

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