Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography
Küçük Resim Yok
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such studies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood now ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateral parietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.
Açıklama
Anahtar Kelimeler
Dysthymic Disorder, Brain Single-Photon Emission Tomography, Technetium-99m Hexamethylpropylene, Amine Oxime, Cerebral Blood-Flow, Mood Disorders, Frontal-Lobe, Depression, Glucose, Hypometabolism, Consumption, Disease
Kaynak
European Journal Of Nuclear Medicine
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
26
Sayı
3
