Effects of Losartan on Glycerol-induced Myoglobinuric Acute Renal Failure in Rats

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorKaya, Oktay
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorTastekin, Ebru
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:07:52Z
dc.date.available2024-06-12T11:07:52Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMyoglobinuric acute renal failure (mARF) is an uremic syndrome which develops due to damage of skeletal muscle. It was demonstrated that free radicals and nitric oxide (NO) play an important role in pathogenesis of mARF. Our aim was to investigate the effect of losartan, a drug known for its antioxidant effect, on mARF. In our study, a total of 34 male Spraque Dawley rats were divided into four groups. 1st and 2nd groups were injected with saline, 3rd and 4th groups were injected with intramuscular glycerol. One and 24 hours later, 1st and 3rd groups received saline orally and 2nd and 4th groups have taken 10 mg/kg losartan. Urine was collected; the blood samples and kidneys of the rats were taken under the anesthesia. The levels of NO, arginine, asymmetric dimethylarginine (ADMA), glutathione (GSH) and malondialdehyde (MDA) were determined, renal functions and histopathological changes examined. In our study, we found that levels of urea, creatinine, and potassium, in serum samples and MDA and ADMA in renal tissue were increased in 3rd group when it's compared with the 1st group. Levels of sodium, arginine in serum samples and arginine in renal tissue were reduced 3rd group when compared with the 1st group. When 3rd and 4th groups were compared, serum creatinine was higher in the latter group whereas ADMA level in renal tissue was lower in the same group. We think that there is no positive effect of losartan on the pathogenesis of mARF.en_US
dc.identifier.doi10.9775/kvfd.2012.7620
dc.identifier.endpage258en_US
dc.identifier.issn1300-6045
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84872798051en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage253en_US
dc.identifier.trdizinid140405en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2012.7620
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/140405
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22198
dc.identifier.volume19en_US
dc.identifier.wosWOS:000321748400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLosartanen_US
dc.subjectMyoglobinuric Acute Renal Failureen_US
dc.subjectFree Radicalsen_US
dc.subjectNitric Oxideen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.subjectNitric-Oxideen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectL-Carnitineen_US
dc.subjectKidneyen_US
dc.subjectRhabdomyolysisen_US
dc.subjectArginineen_US
dc.subjectSerumen_US
dc.titleEffects of Losartan on Glycerol-induced Myoglobinuric Acute Renal Failure in Ratsen_US
dc.typeArticleen_US

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