TERT Expression in Pituitary Adenomas

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dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridSarikas, Nurtac/0000-0002-2170-0300
dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridÇelik, Mehmet/0000-0003-3575-9167;
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidSarikas, Nurtac/ABG-1224-2021
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.contributor.authorCan, Nuray
dc.contributor.authorCelik, Mehmet
dc.contributor.authorBulbul, Buket Yilmaz
dc.contributor.authorSut, Necdet
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorAyturk, Semra
dc.contributor.authorGuldiken, Sibel
dc.date.accessioned2024-06-12T11:12:25Z
dc.date.available2024-06-12T11:12:25Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Although pituitary adenomas have benign histomorphological features, some of them may present in an aggressive manner. To predict the behaviour of these tumours, telomerase reverse transcriptase (TERT) activity in pituitary adenomas has been the subject of a few studies with contradictory results. This study aims to investigate whether immunohistochemical expression of TERT differs in neoplastic and nonneoplastic pituitary tissues and aims to investigate whether TERT expression is related to clinicopathological features of pituitary adenomas. Material and Method: The study included 48 patients who had been diagnosed with pituitary adenomas and had clinical follow-ups. Nonneoplastic pituitary tissues were obtained from autopsy specimens (n=20). Immunohistochemistry for TERT antibody was performed. Both the nuclear and cytoplasmic expression of TERT antibody was noted, and total combined TERT staining was evaluated according to nuclear and cytoplasmic stainings. Results: TERT expression did not differ between neoplastic and nonneoplastic pituitary tissues. Neither total (combined nuclear and cytoplasmic) TERT nor nuclear TERT expression revealed any statistically significant relationship with any of the clinicopathological features. Higher cytoplasmic TERT expression was observed in adenomas with recurrence than adenomas without recurrence (p=0.035). Conclusion: This study introduces the notion that immunohistochemical expression of TERT does not differ in neoplastic and nonneoplastic pituitary tissues. Pituitary adenomas with cytoplasmic immunohistochemical expression of TERT have significantly higher rates of recurrence. Further studies, including combined methods of immunohistochemistry and molecular analyses in larger groups, may reveal applicable results for the clinical significance of TERT in pituitary adenomas.en_US
dc.identifier.doi10.5146/tjpath.2016.01387
dc.identifier.endpage111en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid28272680en_US
dc.identifier.scopus2-s2.0-85018987997en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage103en_US
dc.identifier.trdizinid262317en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2016.01387
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/262317
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23169
dc.identifier.volume33en_US
dc.identifier.wosWOS:000414649400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofTurkish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPituitary Adenomasen_US
dc.subjectTelomerase Reverse Transcriptaseen_US
dc.subjectClinicopathological Featuresen_US
dc.subjectTelomerase Activityen_US
dc.subjectTumorsen_US
dc.subjectProliferationen_US
dc.subjectMutationsen_US
dc.subjectLengthen_US
dc.titleTERT Expression in Pituitary Adenomasen_US
dc.typeArticleen_US

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