Practical Synthesis of Pioglitazone: Ligand Substitution Reaction With Oxido Vanadium(IV) and Biological Activity

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dc.contributor.authorAltun, Ozlen
dc.contributor.authorKucuktepe, Caner
dc.contributor.authorYoruk, Ozan
dc.contributor.authorFeyizoglu, Adilhan
dc.date.accessioned2024-06-12T10:54:38Z
dc.date.available2024-06-12T10:54:38Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe authors performed two types of experiments: the reduction of 5-{4-[2-(5-ethyl-2-pyridyl)etoxy]benzilidine}-24- thiazolidinedione to pioglitazone (5-{4-[2-(5-ethyl-2-pyridyl) etoxy]benzil}-24-thiazolidinedione) with magnesium/methanol and the synthesis of an oxidovanadium(IV) complex of pioglitazone in methanol under refluxing conditions. The structures of pioglitazone and its oxidovanadium(IV) complex were analyzed by using physicochemical and spectroscopic techniques. Comparisons of the spectral measurements of pioglitazone with those of its oxidovanadium(IV) ion complex are useful in determining the atoms of the ligand that are coordinated to the metal ion. In addition, antibacterial and antifungal activities of the complex were studied and the complex is screened against bacteria and fungi.en_US
dc.identifier.doi10.1080/15533174.2012.740708
dc.identifier.endpage225en_US
dc.identifier.issn1553-3174
dc.identifier.issn1553-3182
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84873332605en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1080/15533174.2012.740708
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19118
dc.identifier.volume43en_US
dc.identifier.wosWOS:000314161900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSynthesis And Reactivity In Inorganic Metal-Organic And Nano-Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Activityen_US
dc.subjectMgen_US
dc.subjectMethanolen_US
dc.subjectOxidovanadium(IV)en_US
dc.subjectPioglitazoneen_US
dc.subjectSpectroscopyen_US
dc.subjectReductionen_US
dc.subjectDispositionen_US
dc.subjectMagnesiumen_US
dc.subjectComplexesen_US
dc.subjectChemistryen_US
dc.titlePractical Synthesis of Pioglitazone: Ligand Substitution Reaction With Oxido Vanadium(IV) and Biological Activityen_US
dc.typeArticleen_US

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