Practical Synthesis of Pioglitazone: Ligand Substitution Reaction With Oxido Vanadium(IV) and Biological Activity
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The authors performed two types of experiments: the reduction of 5-{4-[2-(5-ethyl-2-pyridyl)etoxy]benzilidine}-24- thiazolidinedione to pioglitazone (5-{4-[2-(5-ethyl-2-pyridyl) etoxy]benzil}-24-thiazolidinedione) with magnesium/methanol and the synthesis of an oxidovanadium(IV) complex of pioglitazone in methanol under refluxing conditions. The structures of pioglitazone and its oxidovanadium(IV) complex were analyzed by using physicochemical and spectroscopic techniques. Comparisons of the spectral measurements of pioglitazone with those of its oxidovanadium(IV) ion complex are useful in determining the atoms of the ligand that are coordinated to the metal ion. In addition, antibacterial and antifungal activities of the complex were studied and the complex is screened against bacteria and fungi.
Açıklama
Anahtar Kelimeler
Biological Activity, Mg, Methanol, Oxidovanadium(IV), Pioglitazone, Spectroscopy, Reduction, Disposition, Magnesium, Complexes, Chemistry
Kaynak
Synthesis And Reactivity In Inorganic Metal-Organic And Nano-Metal Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
43
Sayı
3
