Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)

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dc.authorwosidTurkyilmaz, Murat/AAK-7876-2020
dc.contributor.authorTurkyilmaz, Murat
dc.contributor.authorGenc, Fatma
dc.date.accessioned2024-06-12T10:54:29Z
dc.date.available2024-06-12T10:54:29Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA new and more effective compound was synthesized by combining bile acid (chenodeoxycholic acid) and phosphazene. The synthesis started with chenodeoxycholic acid (CDCA). In the first step CDCA was converted to the CDCA methyl ester (methyl-4-(hexadecahydro-3,7-dihydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl) pentanoate). The mesylate was prepared from the methyl ester of CDCA and converted to the azide ester of CDCA by an S(N)2 reaction. The azide group at C-3 of chenodeoxycholic acid methyl ester was converted to an amino group (3-methyl-4-(3-amino-hexadecahydro-7-hydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl)pentanoate). Then, this compound was allowed to react with hexachlorocyclotriphosphazene in toluene under an argon atmosphere. The structures of the synthesized chenodeoxycholic acid derivatives and of the new phosphazene compound were confirmed by FTIR, H-1, C-13, P-31, C-13-DEPT NMR, MALDI-TOF mass spectra and elemental analysis.en_US
dc.description.sponsorshipTUBAP Scientific Research Project of Trakya University [TUBAP-2011-59]en_US
dc.description.sponsorshipThe authors thank the TUBAP Scientific Research Project of Trakya University (TUBAP-2011-59)en_US
dc.identifier.doi10.1080/10426507.2014.887080
dc.identifier.endpage1731en_US
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-84945236967en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1723en_US
dc.identifier.urihttps://doi.org/10.1080/10426507.2014.887080
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19073
dc.identifier.volume189en_US
dc.identifier.wosWOS:000345961600013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPhosphorus Sulfur And Silicon And The Related Elementsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Aciden_US
dc.subjectChenodeoxycholic Aciden_US
dc.subjectPhosphazeneen_US
dc.subjectDichlorophosphoryl-P-Trichlorophosphazeneen_US
dc.subjectBile-Acidsen_US
dc.subjectChemistryen_US
dc.subjectHexachlorocyclotriphosphazatrieneen_US
dc.subjectConfigurationen_US
dc.subjectComplexesen_US
dc.subjectLigandsen_US
dc.titleMultistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)en_US
dc.typeArticleen_US

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