Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new and more effective compound was synthesized by combining bile acid (chenodeoxycholic acid) and phosphazene. The synthesis started with chenodeoxycholic acid (CDCA). In the first step CDCA was converted to the CDCA methyl ester (methyl-4-(hexadecahydro-3,7-dihydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl) pentanoate). The mesylate was prepared from the methyl ester of CDCA and converted to the azide ester of CDCA by an S(N)2 reaction. The azide group at C-3 of chenodeoxycholic acid methyl ester was converted to an amino group (3-methyl-4-(3-amino-hexadecahydro-7-hydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl)pentanoate). Then, this compound was allowed to react with hexachlorocyclotriphosphazene in toluene under an argon atmosphere. The structures of the synthesized chenodeoxycholic acid derivatives and of the new phosphazene compound were confirmed by FTIR, H-1, C-13, P-31, C-13-DEPT NMR, MALDI-TOF mass spectra and elemental analysis.
Açıklama
Anahtar Kelimeler
Bile Acid, Chenodeoxycholic Acid, Phosphazene, Dichlorophosphoryl-P-Trichlorophosphazene, Bile-Acids, Chemistry, Hexachlorocyclotriphosphazatriene, Configuration, Complexes, Ligands
Kaynak
Phosphorus Sulfur And Silicon And The Related Elements
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
189
Sayı
11
