CD56, CD57, HBME1, CK19, GALECTIN-3 AND P63 IMMUNOHISTOCHEMICAL STAINS IN DIFFERENTIATING DIAGNOSIS OF THYROID BENIGN/MALIGN LESIONS AND NIFTP

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dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridSarikas, Nurtac/0000-0002-2170-0300
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridAzatcam, Meltem/0000-0002-9439-9213
dc.authorwosidCanberk, Sule/AAL-5645-2020
dc.authorwosidSarikas, Nurtac/ABG-1224-2021
dc.authorwosidCanberk, Sule/AAM-8781-2020
dc.contributor.authorTastekin, Ebru
dc.contributor.authorKeskin, Elif Usturali
dc.contributor.authorCan, Nuray
dc.contributor.authorCanberk, Sule
dc.contributor.authorMut, Ayse Nur Usturali
dc.contributor.authorErdogan, Ezgi Genc
dc.contributor.authorAsa, Nurtac
dc.date.accessioned2024-06-12T11:16:25Z
dc.date.available2024-06-12T11:16:25Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDetection of thyroid carcinoma has been steadily increased in the past few decades. After the recognition of NIFTP, also gain importance to differentiate benign tumors (follicular adenoma) from follicular patterned variants of papillary thyroid carcinoma (invasive and infiltrative follicular variant papillary thyroid carcinoma), and low-risk lesions of thyroid (NIFTP). Follicular patterned proliferations of thyroid still persists as a battle for pathologists. In this study, we aimed to analyze the most commonly used immunohistochemical stains HBME1, CK19, Galectin-3, adding the new ones CD56, CD57, and p63. Study groups were; nodular hyperplasia, follicular adenoma, NIFTP, infiltrative follicular variant PTC, classical variant PTC (CVPTC) and follicular carcinoma. Each group consisted of twenty cases. The sections were stained with CD56, CD57, p63, CK19, HBME1 (Mesotel cell), Galectin-3 antibody. Although the expression of CD56 was high in benign follicular lesions, FC could not be excluded in this group. CD57 was high in malignant follicular group and NIFTP. Interestingly, p63 was found highly expressed in FVPTC, which might be promising to predict invasiveness in follicular group of lesions. CK19, Galectin-3 and HBME1 were found quietly prominent in CVPTC in concordance with the previous reports.en_US
dc.identifier.doi10.5114/PJP.2019.93131
dc.identifier.endpage294en_US
dc.identifier.issn1233-9687
dc.identifier.issue4en_US
dc.identifier.pmid32146798en_US
dc.identifier.scopus2-s2.0-85081207151en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage286en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2019.93131
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24295
dc.identifier.volume70en_US
dc.identifier.wosWOS:000519538900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid Lesionsen_US
dc.subjectDifferential Diagnosisen_US
dc.subjectCK19en_US
dc.subjectGalectin-3en_US
dc.subjectCD56en_US
dc.subjectCD57en_US
dc.subjectP63en_US
dc.subjectHBME1en_US
dc.subjectFollicular Varianten_US
dc.subjectLeu-7 Antigenen_US
dc.subjectExpressionen_US
dc.subjectBenignen_US
dc.subjectCarcinomaen_US
dc.subjectTumorsen_US
dc.subjectCytokeratin-19en_US
dc.subjectCd56/N-Camen_US
dc.subjectNeoplasmsen_US
dc.subjectMarkersen_US
dc.titleCD56, CD57, HBME1, CK19, GALECTIN-3 AND P63 IMMUNOHISTOCHEMICAL STAINS IN DIFFERENTIATING DIAGNOSIS OF THYROID BENIGN/MALIGN LESIONS AND NIFTPen_US
dc.typeArticleen_US

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