CD56, CD57, HBME1, CK19, GALECTIN-3 AND P63 IMMUNOHISTOCHEMICAL STAINS IN DIFFERENTIATING DIAGNOSIS OF THYROID BENIGN/MALIGN LESIONS AND NIFTP
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Vesalius Univ Medical Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Detection of thyroid carcinoma has been steadily increased in the past few decades. After the recognition of NIFTP, also gain importance to differentiate benign tumors (follicular adenoma) from follicular patterned variants of papillary thyroid carcinoma (invasive and infiltrative follicular variant papillary thyroid carcinoma), and low-risk lesions of thyroid (NIFTP). Follicular patterned proliferations of thyroid still persists as a battle for pathologists. In this study, we aimed to analyze the most commonly used immunohistochemical stains HBME1, CK19, Galectin-3, adding the new ones CD56, CD57, and p63. Study groups were; nodular hyperplasia, follicular adenoma, NIFTP, infiltrative follicular variant PTC, classical variant PTC (CVPTC) and follicular carcinoma. Each group consisted of twenty cases. The sections were stained with CD56, CD57, p63, CK19, HBME1 (Mesotel cell), Galectin-3 antibody. Although the expression of CD56 was high in benign follicular lesions, FC could not be excluded in this group. CD57 was high in malignant follicular group and NIFTP. Interestingly, p63 was found highly expressed in FVPTC, which might be promising to predict invasiveness in follicular group of lesions. CK19, Galectin-3 and HBME1 were found quietly prominent in CVPTC in concordance with the previous reports.
Açıklama
Anahtar Kelimeler
Thyroid Lesions, Differential Diagnosis, CK19, Galectin-3, CD56, CD57, P63, HBME1, Follicular Variant, Leu-7 Antigen, Expression, Benign, Carcinoma, Tumors, Cytokeratin-19, Cd56/N-Cam, Neoplasms, Markers
Kaynak
Polish Journal Of Pathology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
70
Sayı
4
