Effect of gel formulation obtained from Fomes fomentarius on bleeding and clotting time: A pilot study

dc.authoridÖzyurt, Anıl/0000-0002-3243-3156
dc.authoridNazli, Hakan/0000-0001-5763-1450
dc.authoridGedik, Gülşah/0000-0003-4147-6729
dc.authorwosidÖzyurt, Anıl/AAY-5407-2020
dc.authorwosidNazli, Hakan/ABI-5317-2020
dc.authorwosidGedik, Gülşah/GWC-6445-2022
dc.contributor.authorGedik, Gulsah
dc.contributor.authorAsan, Hulya
dc.contributor.authorOzyurt, Anil
dc.contributor.authorAlli, Hakan
dc.contributor.authorAsan, Ahmet
dc.contributor.authorNazli, Hakan
dc.contributor.authorSarp, Onder
dc.date.accessioned2024-06-12T11:02:05Z
dc.date.available2024-06-12T11:02:05Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Aims: Fomes fomentarius (L.) Fr. (jar fungus) has been used extensively in the past by surgeons, barbers, dentists, and is therefore called surgeon's fungus. The hemostatic properties of F. fomentarius extracts are important in medicine. The aim of this study was to investigate the effect of the gel formulation obtained from Fames Famentarius on bleeding and clotting time in rat models. Methods: The gel was made for this purpose and a cross-linked polymer of acrylic acid was used as a gelling agent. Results: The outcomes of the characterization analysis indicate the development of a successful gel formulation with optimum characteristics. Data from the antimicrobial study showed a good inhibition zone, with the strongest values against Klebsietta pneumaniae, Candida krusei, C. tropicalis, C. guitliermondii. The gel administration shortened the hemostasis time after bleeding from skin incisions by 63.9% and tail incisions by 55.63% from the original time. For coagulation time, these results are determined as 71.56% from the original time. The gel administration shortened the coagulation time after bleeding from the tail incisions by 69.9% from the original time. Conclusion: Our preliminary study showed that the gel formulation obtained from F. fomentarius is a potent hemostatic agent in a rat-bleeding model.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2020.0001
dc.identifier.endpage223en_US
dc.identifier.issn2587-2087
dc.identifier.issue3en_US
dc.identifier.startpage216en_US
dc.identifier.trdizinid420848en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2020.0001
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/420848
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21146
dc.identifier.volume50en_US
dc.identifier.wosWOS:000605357000010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal Of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFomes Fomentariusen_US
dc.subjectBleeding Timeen_US
dc.subjectCoagulation Timeen_US
dc.subjectL. Fr.en_US
dc.subjectHemorrhageen_US
dc.subjectMushroomen_US
dc.subjectDeliveryen_US
dc.subjectAciden_US
dc.titleEffect of gel formulation obtained from Fomes fomentarius on bleeding and clotting time: A pilot studyen_US
dc.typeArticleen_US

Dosyalar