Evaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populations

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dc.contributor.authorPala, Funda Sibel
dc.contributor.authorTabakcioglu, Kiymet
dc.contributor.authorAlguenes, Cetin
dc.contributor.authorOemuerlue, Imran Kurt
dc.date.accessioned2024-06-12T11:03:21Z
dc.date.available2024-06-12T11:03:21Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: In this study, human leukocyte antigen (HLA) allel frequencies of Thracian Turkish population were determined. Study Design: The study group consisted of 105 tissue donors who live in Thrace region of Turkey for three generations and have similar linguistic features. Polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used for genotyping of HLA-A, B and DRB1 alleles. The most frequent HLA alleles were HLA-A*02 (20.5%), HLA-B*35 (22.9%) and HLA-DR*11 (17.6%). Results: Frequencies of HLA alleles show some variations among different populations because of their highly polymorphic gene structure. Determining the distribution of HLA alleles is one of the most preferred genetical approaches for clarifying the relationship between populations. Conclusion: In this study also, HLA-DR allel frequencies were compared in order to determine the relationship between other Turkish populations and Balkan populations. It is observed that Thracian Turkish population has similar HLA-DR distributions with Balkan populations.en_US
dc.identifier.endpage195en_US
dc.identifier.issn1301-3149
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-70349139675en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21613
dc.identifier.volume25en_US
dc.identifier.wosWOS:000261815500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHLAen_US
dc.subjectThracian Turksen_US
dc.subjectTurkish Populationsen_US
dc.subjectBalkan Populationsen_US
dc.subjectClass-Ien_US
dc.subjectAssociationen_US
dc.subjectPolymorphismen_US
dc.subjectHaplotypesen_US
dc.subjectAllelesen_US
dc.subjectDiseaseen_US
dc.subjectGeneen_US
dc.titleEvaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populationsen_US
dc.typeArticleen_US

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