Evaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populations
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves Yayincilik, Ibrahim Kara
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: In this study, human leukocyte antigen (HLA) allel frequencies of Thracian Turkish population were determined. Study Design: The study group consisted of 105 tissue donors who live in Thrace region of Turkey for three generations and have similar linguistic features. Polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used for genotyping of HLA-A, B and DRB1 alleles. The most frequent HLA alleles were HLA-A*02 (20.5%), HLA-B*35 (22.9%) and HLA-DR*11 (17.6%). Results: Frequencies of HLA alleles show some variations among different populations because of their highly polymorphic gene structure. Determining the distribution of HLA alleles is one of the most preferred genetical approaches for clarifying the relationship between populations. Conclusion: In this study also, HLA-DR allel frequencies were compared in order to determine the relationship between other Turkish populations and Balkan populations. It is observed that Thracian Turkish population has similar HLA-DR distributions with Balkan populations.
Açıklama
Anahtar Kelimeler
HLA, Thracian Turks, Turkish Populations, Balkan Populations, Class-I, Association, Polymorphism, Haplotypes, Alleles, Disease, Gene
Kaynak
Trakya Universitesi Tip Fakultesi Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
25
Sayı
3
