The relationship between 99Tcm-sestamibi uptake and ultrastructural cell types of thyroid tumours

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.contributor.authorSarikaya, A
dc.contributor.authorHuseyinova, G
dc.contributor.authorIrfanoglu, ME
dc.contributor.authorErkmen, N
dc.contributor.authorÇermik, TF
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:16:02Z
dc.date.available2024-06-12T11:16:02Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAlthough several hypotheses have been suggested regarding the accumulation of Tc-99(m)-sestamibi in rumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of Tc-99(m)-sestamibi. Thyroid scintigraphy with Tc-99(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, Tc-99(m)-sestamibi accumulates in thyroid rumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention. ((C) 2001 Lippincott Williams & Wilkins).en_US
dc.identifier.doi10.1097/00006231-200101000-00006
dc.identifier.endpage44en_US
dc.identifier.issn0143-3636
dc.identifier.issue1en_US
dc.identifier.pmid11233550en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1097/00006231-200101000-00006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24173
dc.identifier.volume22en_US
dc.identifier.wosWOS:000166925500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99(M)-MIBIen_US
dc.subjectThyroid Tumouren_US
dc.subjectUltrastructural Cell Typeen_US
dc.subjectTechnetium-99m-Mibi Uptakeen_US
dc.subjectPapillary Carcinomaen_US
dc.subjectPhase Scintigraphyen_US
dc.subjectIn-Vitroen_US
dc.subjectLesionsen_US
dc.subjectTl-201en_US
dc.subjectBenignen_US
dc.subjectHyperparathyroidismen_US
dc.subjectLocalizationen_US
dc.subjectNodulesen_US
dc.titleThe relationship between 99Tcm-sestamibi uptake and ultrastructural cell types of thyroid tumoursen_US
dc.typeArticleen_US

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