The relationship between 99Tcm-sestamibi uptake and ultrastructural cell types of thyroid tumours
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Although several hypotheses have been suggested regarding the accumulation of Tc-99(m)-sestamibi in rumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of Tc-99(m)-sestamibi. Thyroid scintigraphy with Tc-99(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, Tc-99(m)-sestamibi accumulates in thyroid rumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention. ((C) 2001 Lippincott Williams & Wilkins).
Açıklama
Anahtar Kelimeler
Tc-99(M)-MIBI, Thyroid Tumour, Ultrastructural Cell Type, Technetium-99m-Mibi Uptake, Papillary Carcinoma, Phase Scintigraphy, In-Vitro, Lesions, Tl-201, Benign, Hyperparathyroidism, Localization, Nodules
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
22
Sayı
1
