The relation of homocysteine levels with deficit syndrome and working memory in schizophrenic patients

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dc.authoridvardar, mehmet erdal/0000-0002-5836-6174;
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.authorwosidvardar, mehmet erdal/AAB-7287-2021
dc.contributor.authorTuglu, Cengiz
dc.contributor.authorOzcan, Sevilay
dc.contributor.authorErdogan, Yasin
dc.contributor.authorSut, Nejdet
dc.contributor.authorVardar, Erdal
dc.contributor.authorAbay, Ercan
dc.date.accessioned2024-06-12T11:13:55Z
dc.date.available2024-06-12T11:13:55Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: There are many theories about etiology of schizophrenia and many studies are going on to find out a biologic determinant specific for schizophrenia. Single carbon metabolism theory has been suggested for the etiology of schizophrenia. There are also many data about a defect in homocysteine metabolism and increased levels of homocysteine in schizophrenic subjects but the correlation of hyperhomocysteinemia with the clinical reflections and symptom dispersion of schizophrenia has not been studied yet. Methods: For forty-one schizophrenic patients, clinical assessments were performed. The patients were divided into two groups, as deficit syndrome group and nondeficit syndrome group, using the deficit syndrome chart. Various test batteries have been applied to all patients to asses the clinical symptomatology and working memory. Serum homocysteine, vitamin B-12, and folic acid levels were measured concurrently. Results: Homocysteine levels were higher in the study group and mild to moderate hyperhomocysteinemia has been observed at the sample group independent folic acid levels. The homocysteine levels and clinical scale scores did not correlate statistically but folic acid levels did with negative symptomotology and functional disturbance. Conclusion: Serum homocysteine levels were elevated in both male and female schizophrenia patients. Hyperhomocysteinemia with the deficit syndrome as well as working memory did not show a statistically significant correlation. (Anatolian Journal of Psychiatry 2011; 12:169-176)en_US
dc.identifier.endpage176en_US
dc.identifier.issn1302-6631
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-79960682523en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage169en_US
dc.identifier.trdizinid126363en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/126363
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23735
dc.identifier.volume12en_US
dc.identifier.wosWOS:000294932500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectHomocysteineen_US
dc.subjectFolic Aciden_US
dc.subjectDeficit Syndromeen_US
dc.subjectWorking Memoryen_US
dc.subjectYoung Male-Patientsen_US
dc.subjectPlasma Homocysteineen_US
dc.subjectCognitive Deficitsen_US
dc.subjectPrefrontal Cortexen_US
dc.subjectBrain Atrophyen_US
dc.subjectAnimal-Modelsen_US
dc.subjectFolic-Aciden_US
dc.subjectFolateen_US
dc.subjectDysfunctionen_US
dc.subjectSymptomsen_US
dc.titleThe relation of homocysteine levels with deficit syndrome and working memory in schizophrenic patientsen_US
dc.typeArticleen_US

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