High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin

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dc.contributor.authorMemi, Gulsun
dc.contributor.authorOzturk, Levent
dc.contributor.authorPalabiyik, Orkide
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAugust / September / Accepted: September ABSTRACT: The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle. Large amounts of dietary fat intake increase the risk of cardiovascular disease. We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes. Seventy-nine Sprague-Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks. In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25 mu g/kg, i.p), exercise+obestatin (25 mu g/kg, i.p). After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed. Hearts were removed for hemodynamic measurements with the Langendorff apparatus. Blood samples were collected for biochemical measurements. Data were analyzed by Graphpad Prism 6.0. and p<0.05 was accepted as statistically significant. Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated. And the effects of chronic obestatin treatment and exercise were studied together. Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD. Also, obestatin prevents decreasing BNP levels with high -fat consumption. Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements. We believe that obestatin has the potential for the maintenance of cardiac function in HFD.en_US
dc.description.sponsorshipTrakya University Research Project Fund (TUBAP)en_US
dc.description.sponsorshipThis research was funded by the Trakya University Research Project Fund (TUBAP; 2013-18) .en_US
dc.identifier.doi10.29228/jrp.322
dc.identifier.endpage413en_US
dc.identifier.issn2630-6344
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85147272533en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage404en_US
dc.identifier.trdizinid1177589en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.322
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177589
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22829
dc.identifier.volume27en_US
dc.identifier.wosWOS:000992608700031en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectHigh-Fat Dieten_US
dc.subjectLangendorffen_US
dc.subjectObestatinen_US
dc.subjectExerciseen_US
dc.subjectHDLen_US
dc.subjectCardiovascular Functionen_US
dc.subjectNatriuretic-Peptideen_US
dc.subjectIschemiaen_US
dc.subjectGhrelinen_US
dc.subjectCardioprotectionen_US
dc.subjectImpacten_US
dc.titleHigh-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatinen_US
dc.typeArticleen_US

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