Value of biomarker-based diagnostic test in differential diagnosis of hemorrhagic-ischemic stroke
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius Univ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and aim: Stroke is an emergency which threatens life and the third leading cause of death in developed countries and the leading cause of long-term disability. By means of this study, it was aimed to evaluate the position of triage stroke panel in differential diagnosis of acute hemorrhagic stroke and ischemic stroke and sub-types of ischemic stroke. Material and methods: Patients with acute stroke admitted to Emergency Department were prospectively recruited between June 2008-January 2009. BNP, D-dimer, MMP-9, S-100b levels were asseyed. Statistical significance for intergroup differences was assessed by Pearson's X-2 for categorical variables and Mann-Whitney U test or Kruskal-Wallis test for continuous variables. Results and conlusion: A total of 100 consecutive patients with a diagnosis of stroke were evaluated. Of these, 29 (29 %) patients had brain hemorrhages on the computed tomography scan performed the Emergency Department, 71 (71 %) patients had ischemic stroke. It was observed that the intercept obtained as a result of jointly evaluating BNP, D-dimer, MMP9 and S100b is more important in differential diagnosis (p<0.005). We suggest that using a combination of plasma biomarkers may be usefull to ischemic or hemorrhagic stroke for differential diagnosis (Tab. 4, Ref. 22). Full Text in free PDF www.bmj.sk.
Açıklama
Anahtar Kelimeler
Emergency, Stroke, Biomarkers, Matrix-Metalloproteinase Expression, Thrombolytic Therapy, Matrix-Metalloproteinase-9, Transformation
Kaynak
Bratislava Medical Journal-Bratislavske Lekarske Listy
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
112
Sayı
7
