Synthesis and antimicrobial evaluation of novel 5-substituted-2-(p-tert-butylphenyl)benzoxazoles

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dc.authoridKaynak, Okyay/0000-0002-4789-6700;
dc.authorwosidÖkten, Suzan/HJH-6316-2023
dc.authorwosidErol, Meryem/AIC-5790-2022
dc.authorwosidKaynak, Okyay/H-5942-2011
dc.authorwosidarpaci, ozlem temiz/AAH-1281-2020
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.authorwosidOkten, Suzan/HGV-1334-2022
dc.contributor.authorTasci, Meryem
dc.contributor.authorTemiz-Arpaci, Ozlem
dc.contributor.authorKaynak-Onurdag, Fatma
dc.contributor.authorOkten, Suzan
dc.date.accessioned2024-06-12T10:54:24Z
dc.date.available2024-06-12T10:54:24Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present study, a series of nine novel 5-substituted-2-(p-tert-butylphenyl)benzoxazole derivatives have been synthesized and their structures confirmed by spectral techniques and also tested for their antimicrobial activities. The minimum inhibitory concentrations (MIC) of the new benzoxazoles have been determined against standard bacterial and fungal strains and drug-resistant isolates and compared to those of several reference drugs. The new benzoxazole derivatives are found to possess a broad spectrum of antibacterial activity with MIC values of 8-256 mu g/mL. Especially, compound 9 is more active than standard drugs ciprofloxacin and cefotaxime against E. coli isolate with a MIC value of 8 mu g/mL. Also new compounds are less active than fluconazole with a MIC value of 256 mu g/mL against C. albicans and its isolate except for compound 9 that shows better activity other compounds with a MIC value of >4 mu g/mL for their antifungal activity.en_US
dc.description.sponsorshipAnkara University Research Fund [16H0237001]en_US
dc.description.sponsorshipThis work was supported by Ankara University Research Fund (Grant No 16H0237001). The Central Laboratory of the Faculty of Pharmacy of Ankara University supported the acquisition of the NMR and mass spectra and elemental analyses in this work.en_US
dc.identifier.endpage389en_US
dc.identifier.issn0376-4699
dc.identifier.issn0019-5103
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85065676777en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19040
dc.identifier.volume57en_US
dc.identifier.wosWOS:000428228600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication & Information Resources-Niscairen_US
dc.relation.ispartofIndian Journal Of Chemistry Section B-Organic Chemistry Including Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzoxazoleen_US
dc.subjectSynthesisen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectBenzoxazolesen_US
dc.subjectInhibitorsen_US
dc.subjectAnalogsen_US
dc.subjectLyaseen_US
dc.titleSynthesis and antimicrobial evaluation of novel 5-substituted-2-(p-tert-butylphenyl)benzoxazolesen_US
dc.typeArticleen_US

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