Synthesis and antimicrobial evaluation of novel 5-substituted-2-(p-tert-butylphenyl)benzoxazoles
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natl Inst Science Communication & Information Resources-Niscair
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, a series of nine novel 5-substituted-2-(p-tert-butylphenyl)benzoxazole derivatives have been synthesized and their structures confirmed by spectral techniques and also tested for their antimicrobial activities. The minimum inhibitory concentrations (MIC) of the new benzoxazoles have been determined against standard bacterial and fungal strains and drug-resistant isolates and compared to those of several reference drugs. The new benzoxazole derivatives are found to possess a broad spectrum of antibacterial activity with MIC values of 8-256 mu g/mL. Especially, compound 9 is more active than standard drugs ciprofloxacin and cefotaxime against E. coli isolate with a MIC value of 8 mu g/mL. Also new compounds are less active than fluconazole with a MIC value of 256 mu g/mL against C. albicans and its isolate except for compound 9 that shows better activity other compounds with a MIC value of >4 mu g/mL for their antifungal activity.
Açıklama
Anahtar Kelimeler
Benzoxazole, Synthesis, Antimicrobial Activity, Benzoxazoles, Inhibitors, Analogs, Lyase
Kaynak
Indian Journal Of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
57
Sayı
3
