Oxidative Stress in Patients with Scalp Seborrheic Dermatitis
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Croation Dermatovenerological Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Seborrheic dermatitis (SD) is a common, chronic inflammatory skin disease that mainly affects the scalp. The objective of this study was to evaluate the activities of superoxide dismutase (SOD) and catalase (CAT) and the levels of malondialdehyde (MDA) in scraping samples of patients with scalp SD. Thirty consecutive patients with a diagnosis of scalp SD and thirty-one healthy volunteers were enrolled. The samples were obtained by scraping the skin surface of the scalp. SOD and CAT activities and MDA levels were measured in scraping samples by spectrophotometric method. SOD and CAT activities and MDA levels were significantly higher in patients than in controls (p<0.001 all). There was a positive correlation between the severity of the disease and itching scores (contingency coefficient = 0.671, p<0.001). Except for this correlation, there was no significant correlation among age, sex, duration and severity of the disease, itching scores, antioxidant enzymes and MDA levels in the patient group (p>0.05). Cutaneous oxidative stress in patients with SD may play an important role in the pathogenesis of the disease. Further clinical and laboratory evaluation of the oxidant/anti-oxidant system in patients with SD is warranted.
Açıklama
Anahtar Kelimeler
Seborrheic Dermatitis, Oxidative Stress, Superoxide Dismutase, Catalase, Malondialdehyde, Severe Dandruff, Selenium, Management, Moderate, Shampoo, Disease
Kaynak
Acta Dermatovenerologica Croatica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
21
Sayı
2
