Long-term Results of One Cycle of Remote Ischemic Preconditioning Applied Before Elective Percutaneous Coronary Intervention
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Tarih
2018
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Myocardial injury after percutaneous coronary intervention (PCI) is seen frequently. Ischemia/reperfusion injury, side branch occlusion and distal embolization of atherothrombotic debris are the maincauses of myocardial injury. Remote ischemic preconditioning (RIPC) is a promising technique for protectionfrom ischemia/reperfusion injury, but sufficient data of long-term clinical outcomes is not available. In thisstudy we planned to investigate the effect of one cycle of RIPC on major cardiovascular events one year afterelective PCI.Patients and Methods: 102 patients, undergoing elective PCI, with normal baseline cTroponin-I (cTn-I)values, were randomized equally into two groups. Five minutes of ischemic preconditioning was appliedbefore the intervention to the preconditioning group, by inflating blood pressure cuff up-to 200 mmHg on nondominantarm. After 1 year, the clinical outcomes of these patients (angina, heart failure, death, myocardialinfarction, repeat revascularization) were questioned.Results: From a total of 102 patients, 90 could be reached after an year. The mean duration of follow-upwas 432 vs. 423.5 days (p= 0.793). Post-PCI 16th hour cTn-I was insignificantly lower in the preconditioningarm (0.079 ?g/L vs. 0.069 ?g/L, p= 0.074). The incidence of cTn-I elevation 5 fold above the URL (> 0.115?g/L) was lower in the preconditioning group; however, it was also insignificant (24.4% vs. 13.3%, p= 0.301).Death, MI or repeat revascularization rates did not differ between the groups.Conclusion: One cycle of RIPC had no effect on major cardiovascular events (MACE) after elective PCI.
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Anahtar Kelimeler
Kaynak
Koşuyolu Heart Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
2
