Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects

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dc.authoridDireskeneli, Haner/0000-0003-2598-5806
dc.authoridIlgen, Ufuk/0000-0001-6443-6426
dc.authoridemmungil, hakan/0000-0001-5184-4404
dc.authorwosidilgen, ufuk/R-8761-2017
dc.contributor.authorEmmungIl, Hakan
dc.contributor.authorIlgen, Ufuk
dc.contributor.authorDIreskenelI, Rafi Haner
dc.date.accessioned2024-06-12T10:54:04Z
dc.date.available2024-06-12T10:54:04Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPsoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the non-HLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8(+) T cells and occasional germinal centers, loss of regulatory T cell function, and specific autoantibodies such as anti-PsA peptide, anti-LL-37, and anti-ADAMTSL5 are the immunopathological findings suggestive of autoimmunity. 'hese were supported by clinical observations of autoimmune multimorbidity and treatment response to calcineurin/mTOR and co-stimulation inhibition.en_US
dc.identifier.doi10.3906/sag-2011-235
dc.identifier.endpage1614en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid33581710en_US
dc.identifier.scopus2-s2.0-85114628605en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1601en_US
dc.identifier.trdizinid479700en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2011-235
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/479700
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18890
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoantibodyen_US
dc.subjectAutoimmunityen_US
dc.subjectGeneticen_US
dc.subjectPsoriasisen_US
dc.subjectPsoriatic Arthritisen_US
dc.subjectHuman-Leukocyte Antigenen_US
dc.subjectSystemic-Lupus-Erythematosusen_US
dc.subjectGenome-Wide Metaanalysisen_US
dc.subjectQuality-Of-Lifeen_US
dc.subjectHla Class-Ien_US
dc.subjectGene Polymorphismsen_US
dc.subjectSusceptibility Locusen_US
dc.subjectPemphigus-Vulgarisen_US
dc.subjectAssociationen_US
dc.subjectDiseaseen_US
dc.titleAutoimmunity in psoriatic arthritis: pathophysiological and clinical aspectsen_US
dc.typeReview Articleen_US

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