Intramural Component of Venous, Lymphatic, and Perineural Invasion in Colon Cancer: A Threat or an Illusion?

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dc.authoridŞenocak Taşçı, Elif/0000-0002-1686-1628
dc.authoridAytac, Erman/0000-0002-8803-0874
dc.authoridAjredini, Mirac/0000-0002-6795-2351
dc.authorwosidYILDIZ, IBRAHIM/JWA-6293-2024
dc.authorwosidŞenocak Taşçı, Elif/KBD-3048-2024
dc.authorwosidRamoğlu, Nur/HJY-2910-2023
dc.authorwosidAytac, Erman/HLW-2224-2023
dc.contributor.authorOzer, Leyla
dc.contributor.authorTasci, Elif Senocak
dc.contributor.authorMutlu, Arda Ulas
dc.contributor.authorPiyade, Betul
dc.contributor.authorRamoglu, Nur
dc.contributor.authorAjredini, Mirac
dc.contributor.authorGurleyik, Damla
dc.date.accessioned2024-06-12T11:17:52Z
dc.date.available2024-06-12T11:17:52Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Extramural venous invasion is an independent predictor of poor outcome in colorectal cancer, whereas the significance of the intramural component of venous and lymphatic and perineural invasion is unclear. Aims: To evaluate the prognostic impact of intramural components for venous, lymphatic, and perineural invasions and the relation of these invasion patterns with clinicopathological features in patients with colon cancer. Study Design: A retrospective cross-sectional study. Methods: The analysis included 626 patients with colon cancer in stages II and III. All patients were divided into four categories (no invasion, intramural invasion only, extramural invasion only, or both intramural and extramural invasions) for vascular invasion, lymphatic invasion and perineural invasion. The primary outcomes were 5-year disease-free and overall survival. Results: Right-sided (for vascular invasion, 24.7% vs. 33.9%, p = 0.007; for perineural invasion, 34.5% vs. 41.5%, p = 0.034) and dMMR tumors (for vascular invasion, 13.5% vs. 33.5, p < 0.001; for perineural invasion, 25% vs. 41.4%, p = 0.004) exhibited less venous and perineural invasion. Compared with no invasion, presence of intramural invasion only, did not exert any effect on disease-free or overall survival for vascular invasion, lymphatic invasion, and perineural invasion. Multivariate analyses revealed that the presence of both intramural and extramural invasion was independently associated with poor disease-free and overall survival for venous (hazard ratios: 2.39, p = 0.001; hazard ratios: 2.46, p = 0.001), lymphatic (hazard ratios: 2.456, p < 0.001; hazard ratios: 2.13, p = 0.02) and perineural invasion (hazard ratios: 2.99, p < 0.001; hazard ratios: 2.68, p < 0.001), respectively. Conclusion: Our data strongly advocates the importance of reporting intramural and extramural components of invasion since the presence of intramural invasion alone may not be considered as a high-risk factor for systemic recurrence.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2022.2022-6-94
dc.identifier.endpage443en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue6en_US
dc.identifier.pmid36317726en_US
dc.identifier.scopus2-s2.0-85141394412en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage436en_US
dc.identifier.trdizinid1174416en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2022.2022-6-94
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1174416
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24876
dc.identifier.volume39en_US
dc.identifier.wosWOS:000884421200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorectal-Canceren_US
dc.subjectStage-Iien_US
dc.subjectAdjuvant Chemotherapyen_US
dc.subjectVascular Invasionen_US
dc.subjectRecommendationsen_US
dc.subjectRectumen_US
dc.titleIntramural Component of Venous, Lymphatic, and Perineural Invasion in Colon Cancer: A Threat or an Illusion?en_US
dc.typeArticleen_US

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