Efficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosis

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridCan, Guray/0000-0002-6054-9244
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidCAN, GÜRAY/AAA-3274-2020
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorTuncel, Sedat Alpaslan
dc.contributor.authorCan, Guray
dc.contributor.authorCagli, Bekir
dc.contributor.authorKaraca, Turan
dc.contributor.authorDemirtas, Selim
dc.contributor.authorElmaoglu, Muhammed
dc.date.accessioned2024-06-12T10:54:30Z
dc.date.available2024-06-12T10:54:30Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, and on the rats from the BDL - 4 weeks at the end of day 28. Results: When fibrosis scores generated in all groups were evaluated together, a strong negative correlation was detected between fibrosis scores and apparent diffusion coefficient (ADC) values measured using b 100 and b 500. ADC values obtained using b 100 were found to be significantly higher compared to the fibrosis observed in both the BDL - 2 weeks and BDL - 4 weeks groups (P < 0.003 and P < 0.001, respectively). Conclusion: We think that DWI may be an alternative to liver biopsy for the diagnosis and staging of hepatic fibrosis with underlying extrahepatic cholestasis.en_US
dc.identifier.doi10.3906/sag-1403-113
dc.identifier.endpage693en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid26281340en_US
dc.identifier.scopus2-s2.0-84929731485en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage686en_US
dc.identifier.trdizinid172729en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1403-113
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/172729
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19076
dc.identifier.volume45en_US
dc.identifier.wosWOS:000356357800033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectHepatic Fibrosisen_US
dc.subjectDiffusion-Weighted Magnetic Resonanceen_US
dc.subjectExperimental Extrahepatic Cholestasisen_US
dc.subjectRaten_US
dc.subjectLiver Fibrosisen_US
dc.subjectCirrhosisen_US
dc.subjectQuantificationen_US
dc.subjectParametersen_US
dc.subjectSequencesen_US
dc.subjectDiagnosisen_US
dc.subjectLesionsen_US
dc.subjectBiopsyen_US
dc.subjectMrien_US
dc.titleEfficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosisen_US
dc.typeArticleen_US

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