The evaluation of morbidity in gastrointestinal tumor patients underwent cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)

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dc.authoridAytin, Yusuf Emre/0000-0003-2692-4124
dc.contributor.authorAytin, Yusuf Emre
dc.contributor.authorCakcak, Ibrahim Ethem
dc.contributor.authorSagiroglu, Tamer
dc.date.accessioned2024-06-12T11:02:31Z
dc.date.available2024-06-12T11:02:31Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to determine the postoperative morbidity rate and identify demographic, clinical, and treatment-related variables that may be potential risk factors for morbidity in gastrointestinal tumor patients undergoing hyperthermic intraperitoneal chemotherapy (HIPEC) with or without cytoreductive surgery (CRS). Material and Methods: In this retrospective study, 60 patients who had undergone HIPEC due to gastrointestinal tumor between October 2017 and December 2019 were included. Systemic toxicities were graded and evaluated according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 criteria. Results: Mean age of the patients was 60.43 +/- 12.83. Primary tumor localization was the stomach in 33 patients (55%), colon in 21 (35%), rectum in five (8.3%), and appendix in one patient (1.7%). PCI mean value was 9.51 +/- 10.92. CC-0 was applied in 37 (61.7%) patients, CC-1 in 11 (18.3%), CC-2 in 6 (10%), and CC-3 in six patients (10%). Morbidity was observed in 50 (83.33%) of the 60 patients participating in the study according to NCI-CTCAE v3.0 classification. Mild morbidity rate was 46.6%, severe morbidity rate was 36.6%, and mortality rate was 11.66%. Enteric diversion application, length of stay in the ICU, and length of hospital stay were shown to have a statistically significant effect on the NCI-CTCAE morbidity score (p= 0.046, p= 0.004, p< 0.001). Conclusion: With proven beneficial effects on survival in patients with locally advanced gastrointestinal tumors, CRC and HIPEC are acceptable in these patients despite their increased morbidity and mortality rate. With new studies on this subject, morbidity and mortality rates may be reduced.en_US
dc.identifier.doi10.47717/turkjsurg.2023.5706
dc.identifier.endpage26en_US
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue1en_US
dc.identifier.pmid37275924en_US
dc.identifier.scopus2-s2.0-85165047266en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage17en_US
dc.identifier.trdizinid1178978en_US
dc.identifier.urihttps://doi.org/10.47717/turkjsurg.2023.5706
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1178978
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21303
dc.identifier.volume39en_US
dc.identifier.wosWOS:000946256700005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Surgical Assocen_US
dc.relation.ispartofTurkish Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastrointestinal Tumoren_US
dc.subjectCytoreductive Surgeryen_US
dc.subjectHyperthermic Intraperitoneal Chemotherapyen_US
dc.subjectMorbidityen_US
dc.subjectHIPECen_US
dc.subjectAdvanced Gastric-Canceren_US
dc.subjectPeritoneal Carcinomatosisen_US
dc.subjectPseudomyxoma Peritoneien_US
dc.subjectPostoperative Complicationsen_US
dc.subjectSystemic Chemotherapyen_US
dc.subjectLearning-Curveen_US
dc.subjectMortalityen_US
dc.subjectOutcomesen_US
dc.subjectChemoperfusionen_US
dc.subjectMetastasesen_US
dc.titleThe evaluation of morbidity in gastrointestinal tumor patients underwent cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)en_US
dc.typeArticleen_US

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