Assessment of diastolic function in children and adolescents with beta-thalassemia major by tissue Doppler imaging

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dc.authorwosidKARAKAŞ, Zeynep/AAE-1422-2020
dc.authorwosidÖmeroğlu, Rukiye Nurten/AAT-7658-2020
dc.authorwosidnişli, kemal/AAT-6434-2020
dc.contributor.authorYavuz, Taner
dc.contributor.authorNisli, Kemal
dc.contributor.authorOner, Naci
dc.contributor.authorErtugrul, Turkan
dc.contributor.authorSalcioglu, Zafer
dc.contributor.authorAydogan, Gonul
dc.contributor.authorKarakas, Zeynep
dc.date.accessioned2024-06-12T10:54:25Z
dc.date.available2024-06-12T10:54:25Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to analyze myocardial diastolic function in patients with beta-thalassemia major before development of overt cardiomyopathy using pulsed wave tissue Doppler imaging, and compare data with conventional Doppler echocardiography. Material and Method: The study included 61 beta-thalassemia major subjects (age 4 to 20 years; mean age, 10.7 +/- 4.1 years; 32 females and 29 males) with normal left ventricular function and 52 healthy control subjects, matched for age and sex. All participants underwent M-mode echocardiography and left ventricular systolic function was measured; diastolic functions of the right and left ventricul were analysed using tissue Doppler imaging and conventional Doppler echocardiography. SPSS for Windows 13.0 software programme was used for statistical analysis, and the student's t-test was used to compare data. This study was approved by the ethics committee of the Istanbul Medical Faculty. Results: Body surface area was significantly smaller in the patients than in the controls (1.0 +/- 0.2 vs. 1.2 +/- 0.3 m(2), p < 0.01). Transmitral early peak velocity and ratio were found to be significantly increased in patients compared with the controls (p < 0.01 and p=0.039, respectively). Late peak velocity of mitral valve and all Doppler velocities across the tricuspid valve did not differ between groups (p > 0.05). In patients with beta-thalassemia major, the early diastolic velocities of the myocardium at the base of the left and right ventricle, at the middle segment of the left and right ventricle, and the interventricular septum were found to be higher than controls (p < 0.05). We also found significantly higher late diastolic velocities at the base and middle segments of right ventricle, early and late diastolic velocities ratio at the base of the right ventricle and at the middle segment of the left and right ventricle, and the interventricular septum compared with controls (p < 0.05). Conclusions: These findings acquired from the young aged beta-thalassemia major patients with normal ventricular systolic function were believed to be results from high preload and hyperdynamic response to chronic anemia rather than true ventricular restriction. We suggest that long-term follow-up studies should be carried out in patients with beta-thalassemia major using tissue Doppler in order to evaluate the diagnostic accuracy of this imaging technique in diagnosis of early stages of cardiac involvement. (Turk Arch Ped 2011; 46: 26-32)en_US
dc.identifier.doi10.4274/tpa.46.05
dc.identifier.endpage32en_US
dc.identifier.issn1306-0015
dc.identifier.issn1308-6278
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84856670342en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.4274/tpa.46.05
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19048
dc.identifier.volume46en_US
dc.identifier.wosWOS:000288576600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofTurk Pediatri Arsivi-Turkish Archives Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-Thalassemiaen_US
dc.subjectCardiomyopathyen_US
dc.subjectCongestive Heart Failureen_US
dc.subjectDiastolic Heart Faliureen_US
dc.subjectEchocardiographyen_US
dc.subjectTissue Doppler Imagingen_US
dc.subjectMyocardial Iron Overloaden_US
dc.subjectVentricular Functionen_US
dc.subjectEchocardiographyen_US
dc.subjectHemochromatosisen_US
dc.subjectCardiomyopathyen_US
dc.subjectTransfusionen_US
dc.subjectPerformanceen_US
dc.subjectRelaxationen_US
dc.subjectVelocitiesen_US
dc.subjectHearten_US
dc.titleAssessment of diastolic function in children and adolescents with beta-thalassemia major by tissue Doppler imagingen_US
dc.typeArticleen_US

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