Assessment of diastolic function in children and adolescents with beta-thalassemia major by tissue Doppler imaging
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The purpose of this study was to analyze myocardial diastolic function in patients with beta-thalassemia major before development of overt cardiomyopathy using pulsed wave tissue Doppler imaging, and compare data with conventional Doppler echocardiography. Material and Method: The study included 61 beta-thalassemia major subjects (age 4 to 20 years; mean age, 10.7 +/- 4.1 years; 32 females and 29 males) with normal left ventricular function and 52 healthy control subjects, matched for age and sex. All participants underwent M-mode echocardiography and left ventricular systolic function was measured; diastolic functions of the right and left ventricul were analysed using tissue Doppler imaging and conventional Doppler echocardiography. SPSS for Windows 13.0 software programme was used for statistical analysis, and the student's t-test was used to compare data. This study was approved by the ethics committee of the Istanbul Medical Faculty. Results: Body surface area was significantly smaller in the patients than in the controls (1.0 +/- 0.2 vs. 1.2 +/- 0.3 m(2), p < 0.01). Transmitral early peak velocity and ratio were found to be significantly increased in patients compared with the controls (p < 0.01 and p=0.039, respectively). Late peak velocity of mitral valve and all Doppler velocities across the tricuspid valve did not differ between groups (p > 0.05). In patients with beta-thalassemia major, the early diastolic velocities of the myocardium at the base of the left and right ventricle, at the middle segment of the left and right ventricle, and the interventricular septum were found to be higher than controls (p < 0.05). We also found significantly higher late diastolic velocities at the base and middle segments of right ventricle, early and late diastolic velocities ratio at the base of the right ventricle and at the middle segment of the left and right ventricle, and the interventricular septum compared with controls (p < 0.05). Conclusions: These findings acquired from the young aged beta-thalassemia major patients with normal ventricular systolic function were believed to be results from high preload and hyperdynamic response to chronic anemia rather than true ventricular restriction. We suggest that long-term follow-up studies should be carried out in patients with beta-thalassemia major using tissue Doppler in order to evaluate the diagnostic accuracy of this imaging technique in diagnosis of early stages of cardiac involvement. (Turk Arch Ped 2011; 46: 26-32)
Açıklama
Anahtar Kelimeler
Beta-Thalassemia, Cardiomyopathy, Congestive Heart Failure, Diastolic Heart Faliure, Echocardiography, Tissue Doppler Imaging, Myocardial Iron Overload, Ventricular Function, Echocardiography, Hemochromatosis, Cardiomyopathy, Transfusion, Performance, Relaxation, Velocities, Heart
Kaynak
Turk Pediatri Arsivi-Turkish Archives Of Pediatrics
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
46
Sayı
1
