Efficiacy of resveratrol and quercetin after experimental spinal cord injury

Basit Öğe Kaydı
dc.authoridCoşan, Didem Turgut/0000-0002-8488-6405;
dc.authorwosidCoşan, Didem Turgut/ABC-1466-2020
dc.authorwosidUYSAL, ONUR/W-4144-2017
dc.contributor.authorCiftci, Ulvi
dc.contributor.authorDelen, Emre
dc.contributor.authorVural, Murat
dc.contributor.authorUysal, Onur
dc.contributor.authorCosan, Didem Turgut
dc.contributor.authorBaydemir, Canan
dc.contributor.authorDoganer, Fulya
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of this study was to investigate the effect of natural antioxidants resveratrol and quercetin on oxidative stress and secondary cell damage in rats with acute spinal cord injury. METHODS: In this experimental study, 42 male Sprague-Dawley rats were used. Spinal cord injury was performed with clip compression method at level of T4-5. The study was conducted using 6 groups: control, trauma, trauma and solvent, trauma and resveratrol, trauma and quercetin, and trauma with combined resveratrol and quercetin. All rats were euthanized 48 hours after the procedure. Effects of resveratrol and quercetin on serum and tissue total antioxidant capacity and paraoxanase activity level were examined. RESULTS: Compared to trauma group, there was a significant increase in total antioxidant capacity and paraoxanase activity level in resveratrol, quercetin, and combined treatment groups. There was no significant difference between resveratrol and quercetin groups with regard to total antioxidant capacity and paraoxanase activity level. Total antioxidant capacity and paraoxanase activity level were significantly higher in solvent group than trauma group. In histopathological evaluation, there was a decrease in polymorphonuclear leukocyte infiltration in solvent, resveratrol, quercetin, and combined treatment groups. CONCLUSION: Biochemical and histological staining results of present study showed that resveratrol and quercetin may be effective in preventing secondary damage in spinal cord injury.en_US
dc.identifier.doi10.5505/tjtes.2016.44575
dc.identifier.endpage431en_US
dc.identifier.issn1306-696X
dc.identifier.issue5en_US
dc.identifier.pmid27849317en_US
dc.identifier.scopus2-s2.0-84986327476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage423en_US
dc.identifier.trdizinid204156en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2016.44575
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/204156
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18591
dc.identifier.volume22en_US
dc.identifier.wosWOS:000386543000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectExperimental Spinal Cord Injuryen_US
dc.subjectQuercetinen_US
dc.subjectResveratrolen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectHigh-Density-Lipoproteinsen_US
dc.subjectRed Wine Polyphenolen_US
dc.subjectRecoveryen_US
dc.subjectNeuroprotectionen_US
dc.subjectMechanismsen_US
dc.subjectRatsen_US
dc.subjectMethylprednisoloneen_US
dc.subjectAntioxidantsen_US
dc.subjectPolymorphismen_US
dc.titleEfficiacy of resveratrol and quercetin after experimental spinal cord injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu