Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients

Basit Öğe Kaydı
dc.authoridAktas, Gul Ege/0000-0003-4880-2275
dc.authoridDEDE, Fuat/0000-0003-1985-616X
dc.authoriderdil, tanju yusuf/0000-0002-5811-4321
dc.authoridTUROGLU, Halil Turgut/0000-0002-4289-8811
dc.authorwosidAktas, Gul Ege/R-1776-2019
dc.authorwosidErdil, Tanju Yusuf/GLV-4529-2022
dc.authorwosidDEDE, Fuat/Y-1079-2018
dc.contributor.authorAktas, Gul Ege
dc.contributor.authorTuroglu, Halil Turgut
dc.contributor.authorErdil, Tanju Yusuf
dc.contributor.authorInanir, Sabahat
dc.contributor.authorDede, Fuat
dc.date.accessioned2024-06-12T11:09:14Z
dc.date.available2024-06-12T11:09:14Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Geriatric patient population has special importance due to particular challenges. In addition to the increase in incidence of toxic nodular goiter (TNG) with age, it has a high incidence in the regions of low-medium iodine intake such as in our country. The aim of this study was to evaluate the overall outcome of high fixed dose radioiodine (RAI) therapy, and investigate the particular differences in the geriatric patient population. Methods: One hundred and three TNG patients treated with high dose I-131 (370-740 MBq) were retrospectively reviewed. The baseline characteristics; age, gender, scintigraphic patterns and thyroid function tests before and after treatment, as well as follow-up, duration of antithyroid drug (ATD) medication and achievement of euthyroid or hypothyroid state were evaluated. The patient population was divided into two groups as those=>65 years and those who were younger, in order to assess the effect of age. Results: Treatment success was 90% with single dose RAI therapy. Hyperthyroidism was treated in 7 +/- 7, 2 months after RAI administration. At the end of the first year, overall hypothyroidism rate was 30% and euthyroid state was achieved in 70% of patients. Age was found to be the only statistically significant variable effecting outcome. A higher ratio of euthyroidism was achieved in the geriatric patient population. Conclusion: High fixed dose I-131 treatment should be preferred in geriatric TNG patients in order to treat persistent hyperthyroidism rapidly. The result of this study suggests that high fixed dose RAI therapy is a successful modality in treatni g TNG, and high rates of euthyroidism can be achieved in geriatric patients.en_US
dc.identifier.doi10.4274/mirt.57060
dc.identifier.endpage99en_US
dc.identifier.issn2146-1414
dc.identifier.issn2147-1959
dc.identifier.issue3en_US
dc.identifier.pmid27529883en_US
dc.identifier.startpage94en_US
dc.identifier.trdizinid193351en_US
dc.identifier.urihttps://doi.org/10.4274/mirt.57060
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/193351
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22740
dc.identifier.volume24en_US
dc.identifier.wosWOS:000217721000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMolecular Imaging And Radionuclide Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNodular Goiteren_US
dc.subjectI-131en_US
dc.subjectGeriatricsen_US
dc.subjectHyperthyroidismen_US
dc.titleLong-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu