Value of Dynamic Contrast-Enhanced MRI and Correlation with Tumor Angiogenesis in Bladder Cancer

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dc.authoridDemir, Mustafa Kemal/0000-0002-7023-6153
dc.authorwosidDemir, Mustafa/E-2809-2019
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.contributor.authorTuncbilek, Nermin
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorAltaner, Semsi
dc.contributor.authorAtakan, Irfan H.
dc.contributor.authorSut, Necdet
dc.contributor.authorInci, Osman
dc.contributor.authorDemir, Mustafa Kemal
dc.date.accessioned2024-06-12T10:51:42Z
dc.date.available2024-06-12T10:51:42Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description25th National Radiology Congress -- 2004 -- Antalya, TURKEYen_US
dc.description.abstractOBJECTIVE. The aim of this study was to investigate dynamic contrast-enhanced MRI (DCE-MRI) for the noninvasive measurement of bladder cancer angiogenesis by correlation with microvessel density, histologic grade, and tumor staging, and to predict the outcome of local recurrence. MATERIALS AND METHODS. Twenty-four patients with bladder cancer were examined using DCE-MRI. Hemodynamic parameters obtained by DCE-MRI included peak time enhancement in the first minute (E-max/1) after contrast administration, second minute (E-max/2), third minute (E-max/3), fourth minute (E (max/4)), and fifth minute (E-max/5), and the steepest slope. Microvessel density was identified by immunostaining of endothelial cells using FVIII-related antigen. The Mann-Whitney U test, multivariate discriminant analysis, Spearman's correlation coefficient, and analysis of variance were used for statistical analysis. RESULTS. Correlation was seen between DCE-MRI parameters (E-max/1 and steepest slope) and microvessel density (p<0.05). E-max/1 and steepest slope were found to have a statistically significant correlation with histologic grade (p<0.05 and p<0.01, respectively). A significant difference was seen between groups of patients with and without local recurrence with regard to two of the DCE-MRI parameters (p<0.05 for E-max/1 and E-max/2). CONCLUSION. The contrast enhancement patterns on DCE-MRI are influenced by tumor angiogenesis, as reflected by elevated microvessel density expression. Therefore, they are valuable indicators for assessing tumor angiogenic activity and tumor neovascularization in bladder cancers.en_US
dc.identifier.doi10.2214/AJR.08.1332
dc.identifier.endpage955en_US
dc.identifier.issn0361-803X
dc.identifier.issn1546-3141
dc.identifier.issue4en_US
dc.identifier.pmid19304699en_US
dc.identifier.scopus2-s2.0-63849281025en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage949en_US
dc.identifier.urihttps://doi.org/10.2214/AJR.08.1332
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18459
dc.identifier.volume192en_US
dc.identifier.wosWOS:000264358900018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Roentgen Ray Socen_US
dc.relation.ispartofAmerican Journal Of Roentgenologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBladder Canceren_US
dc.subjectDynamic Enhancementen_US
dc.subjectMRIen_US
dc.subjectTransitional-Cell Carcinomaen_US
dc.subjectInvasive Breast-Canceren_US
dc.subjectPrognostic-Significanceen_US
dc.subjectMicrovessel Densityen_US
dc.subjectChemotherapyen_US
dc.subjectMetastasisen_US
dc.subjectRecurrenceen_US
dc.subjectExpressionen_US
dc.subjectFeaturesen_US
dc.subjectImagesen_US
dc.titleValue of Dynamic Contrast-Enhanced MRI and Correlation with Tumor Angiogenesis in Bladder Canceren_US
dc.typeConference Objecten_US

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