Value of Dynamic Contrast-Enhanced MRI and Correlation with Tumor Angiogenesis in Bladder Cancer
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Roentgen Ray Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE. The aim of this study was to investigate dynamic contrast-enhanced MRI (DCE-MRI) for the noninvasive measurement of bladder cancer angiogenesis by correlation with microvessel density, histologic grade, and tumor staging, and to predict the outcome of local recurrence. MATERIALS AND METHODS. Twenty-four patients with bladder cancer were examined using DCE-MRI. Hemodynamic parameters obtained by DCE-MRI included peak time enhancement in the first minute (E-max/1) after contrast administration, second minute (E-max/2), third minute (E-max/3), fourth minute (E (max/4)), and fifth minute (E-max/5), and the steepest slope. Microvessel density was identified by immunostaining of endothelial cells using FVIII-related antigen. The Mann-Whitney U test, multivariate discriminant analysis, Spearman's correlation coefficient, and analysis of variance were used for statistical analysis. RESULTS. Correlation was seen between DCE-MRI parameters (E-max/1 and steepest slope) and microvessel density (p<0.05). E-max/1 and steepest slope were found to have a statistically significant correlation with histologic grade (p<0.05 and p<0.01, respectively). A significant difference was seen between groups of patients with and without local recurrence with regard to two of the DCE-MRI parameters (p<0.05 for E-max/1 and E-max/2). CONCLUSION. The contrast enhancement patterns on DCE-MRI are influenced by tumor angiogenesis, as reflected by elevated microvessel density expression. Therefore, they are valuable indicators for assessing tumor angiogenic activity and tumor neovascularization in bladder cancers.
Açıklama
25th National Radiology Congress -- 2004 -- Antalya, TURKEY
Anahtar Kelimeler
Angiogenesis, Bladder Cancer, Dynamic Enhancement, MRI, Transitional-Cell Carcinoma, Invasive Breast-Cancer, Prognostic-Significance, Microvessel Density, Chemotherapy, Metastasis, Recurrence, Expression, Features, Images
Kaynak
American Journal Of Roentgenology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
192
Sayı
4
