A comparison of the vasodilatory effects of verapamil, papaverine and nitroglycerin on isolated rat aorta

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dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authorwosidHalici, Umit/AAL-7079-2020
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidHalici, Umit/C-4015-2019
dc.contributor.authorEge, Turan
dc.contributor.authorHalici, Umit
dc.contributor.authorGur, Ozcan
dc.contributor.authorGurkan, Selami
dc.contributor.authorGur, Demet Ozkaramanli
dc.contributor.authorDuran, Enver
dc.date.accessioned2024-06-12T10:52:14Z
dc.date.available2024-06-12T10:52:14Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aims to compare the vasodilatory effects of verapamil, papaverine and nitroglycerin on rat aortic preparations in in vitro isolated tissue bath system and to evaluate the role of vascular endothelium on vasodilatory responses of the isolated rat aorta samples. Methods: The thoracic aorta segments collected from 30 male Wistar rats (20 endothelialized and 20 de-endothelialized vascular rings for each drug in 2 mm wide strips, total number of 120 vascular rings) were suspended into the Krebs solution of the isolated tissue bath system. Phenylephrine was used to induce isometric contraction and tissue samples were treated with verapamil, papaverine and nitroglycerin separately to draw concentration-response curves of isometric vasodilatory responses. This procedure was repeated for de-endothelialized aorta samples. Results: Papaverine and verapamil induced vasodilatatory responses starting from the concentration of 10(-8) M and reached its maximum at concentration of 10(-3) M, while nitroglycerin induced vasodilation at lower concentrations starting from a concentration of 10(-12) M, reaching its maximum at 10(-6) M. Nitroglycerin was the most potent agent, followed by verapamil and papaverine. Efficacy analysis revealed that the most efficient agents were papaverine (140 +/- 6.7%), nitroglycerin (110.8 +/- 1.35%) and verapamil (99 +/- 4.14%), respectively. The results were similar in aorta samples without endothelium (p >= 0.05, F test). Conclusion: In this study examining isolated rat aorta, nitroglycerin was the most potent agent, while papaverine was the most efficient agent. Our study results showed that endothelium played no role in vasodilatation responses of these drugs.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2013.7870
dc.identifier.endpage1009en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84889608443en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1005en_US
dc.identifier.trdizinid151565en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2013.7870
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/151565
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18641
dc.identifier.volume21en_US
dc.identifier.wosWOS:000326410100023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAortaen_US
dc.subjectNitroglycerinen_US
dc.subjectPapaverineen_US
dc.subjectVasodilatationen_US
dc.subjectVerapamilen_US
dc.subjectInternal Thoracic Arteryen_US
dc.subjectRabbit Aortaen_US
dc.subjectRelaxationen_US
dc.subjectEndotheliumen_US
dc.subjectPhenoxybenzamineen_US
dc.subjectToleranceen_US
dc.subjectResponsesen_US
dc.subjectNitrateen_US
dc.titleA comparison of the vasodilatory effects of verapamil, papaverine and nitroglycerin on isolated rat aortaen_US
dc.typeArticleen_US

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