Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease

Küçük Resim Yok

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Assoc Medica Brasileira

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

OBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39-49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050-1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis.

Açıklama

Anahtar Kelimeler

Atherosclerosis, Coronary Artery Disease, Nonalcoholic Fatty Liver Disease, Artery-Disease, Association, Severity, Steatosis, Plaques

Kaynak

Revista Da Associacao Medica Brasileira

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

68

Sayı

10

Künye