Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorSayin, M
dc.contributor.authorVarol, FG
dc.contributor.authorSayin, NC
dc.date.accessioned2024-06-12T11:12:48Z
dc.date.available2024-06-12T11:12:48Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description19th European Congress of Perinatal Medicine -- OCT 14-16, 2004 -- Athens, GREECEen_US
dc.description.abstractObjective: To evaluate the role of natural coagulation inhibitors in various classifications of pregnancy associated hypertension in Turkish population living in Trakya region of Turkey. Study design: Serum uric acid levels, plasma protein C (PC), protein S (PS), antithrombin III (AT 111) activities and activated protein C resistance (APCR) were measured in 80 pregnant women with hypertension (preeclampsia, n = 32; severe preeclampsia, n = 25; eclampsia, n = 14; chronic hypertension, n = 9) and 58 healthy pregnant women. Tukey and Tamhane multiple comparison tests, Kruskal-Wallis, X 2 and Fisher's exact tests were performed for comparison of means and/or medians. Results: Serum uric acid levels were significantly elevated in women with preeclampsia and severe preeclampsia, but PS activity decreased in women with severe preeclampsia (33.2 +/- 18.9% versus 50.4 +/- 22.7%, p = 0.015) and chronic hypertension (29.5 +/- 14.5% versus 50.4 22.7%, p = 0.045) compared to healthy controls. There was no significant difference in APCR, and PC or AT III activity between the groups. Platelet counts were significantly lower in women with severe preeclampsia, compared to controls and women with chronic hypertension. Conclusion(s): Serum uric acid levels and plasma protein S activity may be useful as indices of severity of pathology in pregnancy associated hypertension. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipEuropean Assoc Perinatal Meden_US
dc.identifier.doi10.1016/j.ejogrb.2005.03.020
dc.identifier.endpage187en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue2en_US
dc.identifier.pmid15893867en_US
dc.identifier.scopus2-s2.0-28444462906en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2005.03.020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23303
dc.identifier.volume123en_US
dc.identifier.wosWOS:000234101900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregnancyen_US
dc.subjectHypertensionen_US
dc.subjectPreeclampsiaen_US
dc.subjectCoagulation Inhibitorsen_US
dc.subjectTurkish Populationen_US
dc.subjectActivated Protein-Cen_US
dc.subjectFactor-V-Leidenen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectInherited Thrombophiliaen_US
dc.subjectSevere Preeclampsiaen_US
dc.subjectResistanceen_US
dc.subjectMarkersen_US
dc.subjectDisordersen_US
dc.subjectMutationen_US
dc.subjectWomenen_US
dc.titleEvaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancyen_US
dc.typeConference Objecten_US

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