Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the role of natural coagulation inhibitors in various classifications of pregnancy associated hypertension in Turkish population living in Trakya region of Turkey. Study design: Serum uric acid levels, plasma protein C (PC), protein S (PS), antithrombin III (AT 111) activities and activated protein C resistance (APCR) were measured in 80 pregnant women with hypertension (preeclampsia, n = 32; severe preeclampsia, n = 25; eclampsia, n = 14; chronic hypertension, n = 9) and 58 healthy pregnant women. Tukey and Tamhane multiple comparison tests, Kruskal-Wallis, X 2 and Fisher's exact tests were performed for comparison of means and/or medians. Results: Serum uric acid levels were significantly elevated in women with preeclampsia and severe preeclampsia, but PS activity decreased in women with severe preeclampsia (33.2 +/- 18.9% versus 50.4 +/- 22.7%, p = 0.015) and chronic hypertension (29.5 +/- 14.5% versus 50.4 22.7%, p = 0.045) compared to healthy controls. There was no significant difference in APCR, and PC or AT III activity between the groups. Platelet counts were significantly lower in women with severe preeclampsia, compared to controls and women with chronic hypertension. Conclusion(s): Serum uric acid levels and plasma protein S activity may be useful as indices of severity of pathology in pregnancy associated hypertension. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Açıklama
19th European Congress of Perinatal Medicine -- OCT 14-16, 2004 -- Athens, GREECE
Anahtar Kelimeler
Pregnancy, Hypertension, Preeclampsia, Coagulation Inhibitors, Turkish Population, Activated Protein-C, Factor-V-Leiden, Tumor-Necrosis-Factor, Inherited Thrombophilia, Severe Preeclampsia, Resistance, Markers, Disorders, Mutation, Women
Kaynak
European Journal Of Obstetrics & Gynecology And Reproductive Biology
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
123
Sayı
2
