Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats

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dc.authoridDOĞAN, AYTEN/0000-0003-2525-785X
dc.authoridDoganlar, Zeynep Banu/0000-0002-1365-9897
dc.authoridUZUN, Metehan/0000-0003-1406-5473
dc.authoridDEMİR, Ufuk/0000-0002-0020-1633
dc.authorwosidDoğanlar, Oğuzhan/A-2315-2019
dc.authorwosidDOĞAN, AYTEN/ABA-6754-2020
dc.authorwosidDoganlar, Zeynep Banu/B-4845-2008
dc.authorwosidUZUN, Metehan/JWR-0343-2024
dc.authorwosidDEMİR, Ufuk/GLV-2038-2022
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorGuclu, Orkut
dc.contributor.authorDemir, Ufuk
dc.contributor.authorDogan, Ayten
dc.contributor.authorUzun, Metehan
dc.date.accessioned2024-06-12T11:12:48Z
dc.date.available2024-06-12T11:12:48Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods The fetal heart samples were obtained from melatonin administrated RUPP rats Results Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.en_US
dc.identifier.doi10.1080/10641955.2020.1802595
dc.identifier.endpage443en_US
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue4en_US
dc.identifier.pmid32791955en_US
dc.identifier.scopus2-s2.0-85089448762en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1080/10641955.2020.1802595
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23291
dc.identifier.volume39en_US
dc.identifier.wosWOS:000559565100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHypertension In Pregnancyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectHearten_US
dc.subjectFetusen_US
dc.subjectApoptosisen_US
dc.subjectOxidative Stressen_US
dc.subjectMelatoninen_US
dc.subjectReduced Uterine Perfusionen_US
dc.subjectExpressionen_US
dc.subjectHypoxiaen_US
dc.subjectHypertensionen_US
dc.subjectAntioxidanten_US
dc.subjectPregnancyen_US
dc.subjectPressureen_US
dc.subjectDiseaseen_US
dc.subjectLevelen_US
dc.subjectSerumen_US
dc.titleMelatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP ratsen_US
dc.typeArticleen_US

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