Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods The fetal heart samples were obtained from melatonin administrated RUPP rats Results Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.
Açıklama
Anahtar Kelimeler
Preeclampsia, Heart, Fetus, Apoptosis, Oxidative Stress, Melatonin, Reduced Uterine Perfusion, Expression, Hypoxia, Hypertension, Antioxidant, Pregnancy, Pressure, Disease, Level, Serum
Kaynak
Hypertension In Pregnancy
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
39
Sayı
4
