Neutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuries

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dc.authoridDagdelen, Daghan/0000-0002-2523-9195;
dc.authorwosidaytug, Kamuran Zeynep/ACG-3892-2022
dc.authorwosidDagdelen, Daghan/Y-8418-2018
dc.authorwosidDagdelen, Daghan/JNE-9049-2023
dc.contributor.authorYuce, Erkan
dc.contributor.authorSevim, Kamuran Zeynep
dc.contributor.authorKiyak, Medeni Volkan
dc.contributor.authorYildiz, Kemalettin
dc.contributor.authorDagdelen, Daghan
dc.contributor.authorIrmak, Fatih
dc.contributor.authorKarsidag, Semra
dc.date.accessioned2024-06-12T10:59:12Z
dc.date.available2024-06-12T10:59:12Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Degloving hand injuries have generally been viewed as among the most difficult of injuries to manage due to the extensive nature of associated damage. The traditional approach to the circumferentially degloved segment of problematic flap viability has been to resuture the flap and to wait and see. However, the waiting period or the specific hemorheological protocol remains uncertain. This study aims to acknowledge if Sivelestat, known to ameliorate ischemia-reperfusion injury, enhances the survival of avulsed flaps in a hind limb degloving model of rats and to compare Sivelestat's effects to Pentoxifylline. Methods: In this study, total flap area (cm2), area of necrosis in the flap (cm(2)), and the ratio between the necrotic and total areas (percentage) were determined. Angiogenesis among the groups was documented with CD31, anti-PECAM staining. TUNEL assay was performed to allow the visualization of cell nuclei containing fragmented DNA, a typical feature of apoptosis. Results: The findings obtained in this study showed that Sivelestat administered at 10 mg/kg/hour dosage will inhibit the ischemia-reperfusion injury more pertinently than Pentoxifylline, which exerts only hemorheological effects. Conclusion: The anti-inflammatory effects of Sivelestat will be beneficial for decreasing the early complications of degloving injury, such as inflammation, sepsis, and edema, better than Pentoxifylline, which exerts only hemorheological effects.en_US
dc.identifier.doi10.14744/SEMB.2018.45077
dc.identifier.endpage175en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue2en_US
dc.identifier.pmid32617053en_US
dc.identifier.startpage169en_US
dc.identifier.trdizinid370991en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2018.45077
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/370991
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20360
dc.identifier.volume54en_US
dc.identifier.wosWOS:000542499100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofMedical Bulletin Of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDegloving Injuryen_US
dc.subjectNeutrophil Elastase Inhibitoren_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectDermal Regeneration Templateen_US
dc.subjectRing Avulsionen_US
dc.subjectSkinen_US
dc.subjectPentoxifyllineen_US
dc.subjectReconstructionen_US
dc.subjectRevascularizationen_US
dc.subjectClassificationen_US
dc.subjectApoptosisen_US
dc.titleNeutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuriesen_US
dc.typeArticleen_US

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